1441070-77-4

Basic information

• Product Name: ethyl 3-[2-[2-(benzyloxy)ethyl]-6-nitrophenyl]-2-oxopropanoate
• Synonyms: ethyl 3-[2-[2-(benzyloxy)ethyl]-6-nitrophenyl]-2-oxopropanoate
• CAS NO: 1441070-77-4
• Molecular Weight: 371.39
• Mol File: 1441070-77-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 3-[2-[2-(benzyloxy)ethyl]-6-nitrophenyl]-2-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-[2-[2-(benzyloxy)ethyl]-6-nitrophenyl]-2-oxopropanoate(1441070-77-4)
• EPA Substance Registry System: ethyl 3-[2-[2-(benzyloxy)ethyl]-6-nitrophenyl]-2-oxopropanoate(1441070-77-4)

Safety Data

• Hazardous Substances Data: 1441070-77-4(Hazardous Substances Data)

Upstream product

• 1426679-26-6 1-[(2-methyl-3-nitrophenethyloxy)methyl]benzene 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 139122-19-3 4-(2'-hydroxyethyl)-1,3-dihydro-2H-indol-2-one 
• 120427-93-2 4-ethylenyl-1,3-dihydro-2H-indol-2-one 
• 1426679-27-7 2-[2-[2-(benzyloxy)ethyl]-6-nitrophenyl]acetic acid 
• 120427-96-5 4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one 
• 139122-20-6 2-(2-oxo-2,3-dihydro-1H-indol-4-yl)ethyl-4-methylbenzene-1-sulfonate 

Relevant articles and documents

A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitors

This paper describes a practical approach to the preparation of 4-(2-hydroxyethyl)indolin-2-one, a key intermediate in the synthesis of dopaminergic agonists such as ropinirole - a drug used in the treatment of Parkinson's disease and restless legs syndrome - and of two sets of protein kinase inhibitors. The sequence starts from commercially available 2-(2-methyl-3-nitrophenyl)acetic acid, which is converted in five steps into the desired target compound. This procedure offers a convenient alternative route to existing methodologies, given its milder reaction conditions, ease of implementation, and its overall yield (59 %).