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120427-93-2

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120427-93-2 Usage

Chemical Properties

Beige Solid

Uses

Different sources of media describe the Uses of 120427-93-2 differently. You can refer to the following data:
1. Decomposition product of Ropinirole N-oxide
2. Decomposition product of Ropinirole N-oxide.

Check Digit Verification of cas no

The CAS Registry Mumber 120427-93-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,4,2 and 7 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 120427-93:
(8*1)+(7*2)+(6*0)+(5*4)+(4*2)+(3*7)+(2*9)+(1*3)=92
92 % 10 = 2
So 120427-93-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO/c1-2-7-4-3-5-9-8(7)6-10(12)11-9/h2-5H,1,6H2,(H,11,12)

120427-93-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-ethenyl-1,3-dihydroindol-2-one

1.2 Other means of identification

Product number -
Other names 2H-Indol-2-one,4-ethenyl-1,3-dihydro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120427-93-2 SDS

120427-93-2Downstream Products

120427-93-2Relevant articles and documents

A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitors

Matera, Carlo,Quadri, Marta,Pelucchi, Silvia,De Amici, Marco,Dallanoce, Clelia

, p. 1139 - 1144 (2014/06/24)

This paper describes a practical approach to the preparation of 4-(2-hydroxyethyl)indolin-2-one, a key intermediate in the synthesis of dopaminergic agonists such as ropinirole - a drug used in the treatment of Parkinson's disease and restless legs syndrome - and of two sets of protein kinase inhibitors. The sequence starts from commercially available 2-(2-methyl-3-nitrophenyl)acetic acid, which is converted in five steps into the desired target compound. This procedure offers a convenient alternative route to existing methodologies, given its milder reaction conditions, ease of implementation, and its overall yield (59 %).

Some synthetic approaches to ropinirole (SK and F 101468-A): A potent dopamine receptor agonist

Hayler,Howie,Giles,Negus,Oxley,Walsgrove,Walsh,Dagger,Fortunak,Mastrocola

, p. 875 - 882 (2007/10/02)

Three new routes to ropinirole (SK and F 101468-A, 1) are described each involving the preparation of 3-chlorooxindole intermediates of type 3 from β-nitrostyrenes as the pivotal step. The superiority of sulphonate esters 17a-c as direct precursors to 1 over the bromide 11 is also described.

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