1426679-27-7

Basic information

• Product Name: 2-[2-[2-(benzyloxy)ethyl]-6-nitrophenyl]acetic acid
• Synonyms: 2-[2-[2-(benzyloxy)ethyl]-6-nitrophenyl]acetic acid
• CAS NO: 1426679-27-7
• Molecular Weight: 315.326
• Mol File: 1426679-27-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-[2-[2-(benzyloxy)ethyl]-6-nitrophenyl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-[2-(benzyloxy)ethyl]-6-nitrophenyl]acetic acid(1426679-27-7)
• EPA Substance Registry System: 2-[2-[2-(benzyloxy)ethyl]-6-nitrophenyl]acetic acid(1426679-27-7)

Safety Data

• Hazardous Substances Data: 1426679-27-7(Hazardous Substances Data)

Usage

Derivative of acetic acid

The compound is derived from acetic acid, which is a common building block in organic chemistry.

Contains a nitrophenyl group

The compound has a nitrophenyl group (a phenyl ring with a nitro group attached) which may contribute to its biological activity.

Contains an ethylbenzyl ether group

The compound has an ethylbenzyl ether group (an ethyl group attached to a benzyl group via an oxygen atom) which may also contribute to its biological activity.

Potential applications in the pharmaceutical industry

The compound has potential applications in the development of drugs targeting specific biological pathways.

Versatile building block for synthesis

The complex structure and functional groups of the compound make it a useful building block for the synthesis of various biologically active compounds.

Potential therapeutic properties

The compound may have potential therapeutic properties and is of interest for further research and development in the field of medicinal chemistry.

Upstream product

• 1441070-77-4 ethyl 3-[2-[2-(benzyloxy)ethyl]-6-nitrophenyl]-2-oxopropanoate 
• 23876-15-5 2-(3-nitro-2-methylphenyl)acetic acid 
• 1426679-26-6 1-[(2-methyl-3-nitrophenethyloxy)methyl]benzene 
• 855382-76-2 2-(2-methyl-3-nitrophenyl)ethyl alcohol 

Downstream Products

• 139122-19-3 4-(2'-hydroxyethyl)-1,3-dihydro-2H-indol-2-one 
• 120427-93-2 4-ethylenyl-1,3-dihydro-2H-indol-2-one 
• 120427-96-5 4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one 
• 139122-20-6 2-(2-oxo-2,3-dihydro-1H-indol-4-yl)ethyl-4-methylbenzene-1-sulfonate 

Relevant articles and documents

A process for preparing 4 - (2 - hydroxyethyl) - 1, 3 - dihydro - 2H - indole -2 - one of the new method

The invention discloses a novel method for preparing a ropinirole hydrochloride key intermediate 4-(2-ethoxy)-1,3-dihydro-2H-indole-2-ketone (I). The reaction process comprises the following steps of: carrying out reduction reaction on 2-methyl-3-nitrobenzene acetic acid (III) to generate 2-methyl-3-nitrobenzene ethanol (IV); protecting the hydroxyl of the compound (IV) to generate 2-methyl-3-(2-alkoxy ethyl) nitrobenzene (V); reacting the compound (V) with diethyl oxalate to generate a 2-nitro-6-(2-alkoxy ethyl)-phenyl acetyl formic acid compound (VI); reacting the compound (VI) with hydrogen peroxide to generate 2-nitro-6-(2-alkoxy ethyl)-phenylacetic acid (VII); and carrying out oxidation reaction on the compound (VII) to obtain 4-(2-ethoxy)-1,3-dihydro-2H-indole-2-ketone (I).

A new scalable route to 4-(2-hydroxyethyl)-1,3-dihydro-2 H-indol-2-one: A key intermediate for ropinirole hydrochloride

A new and efficient manufacturing technology is disclosed in the present work for the preparation of 4-(2-hydroxyethyl)-1,3-dihydro-2H-indol-2-one, which is a key intermediate for ropinirole hydrochloride. The whole process gives the target molecule in 71% overall yield with 99% purity. In the final step, a novel nitro reduction/ring-closing/debenzylation takes place in one pot. All the intermediates can be used directly for the next step without purification in this process.