144181-30-6Relevant articles and documents
1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3
Christopher, John A.,Atkinson, Francis L.,Bax, Benjamin D.,Brown, Murray J.B.,Champigny, Aurelie C.,Chuang, Tsu Tshen,Jones, Emma J.,Mosley, Julie E.,Musgrave, James R.
scheme or table, p. 2230 - 2234 (2009/12/25)
A series of 1-aryl-3,4-dihydroisoquinoline inhibitors of JNK3 are described. Compounds 20 and 24 are the most potent inhibitors (pIC50 7.3 and 6.9, respectively in a radiometric filter binding assay), with 10- and 1000-fold selectivity over JNK2 and JNK1,