1442447-50-8Relevant articles and documents
Di-substituted maleic amide linker for antibody drug conjugating and preparation method and use thereof
-
, (2021/04/28)
Provided in the present invention are a di-substituted maleic amide linker conjugated to an antibody and a preparation method and use thereof. In particular, the present invention conjugates a strongly cytotoxic active substance to a biomacromolecule thro
Reversible surface functionalisation of emulsionlated porous polymers using dithiophenol maleimide functional macromolecules
Eissa,Wilson,Chen,Collins,Walker,Haddleton,Cameron
supporting information, p. 9789 - 9792 (2017/09/07)
A new facile and efficient route for the chemical functionalisation of thiol-acrylate polyHIPE materials with responsive macromolecules using the highly emissive dithiomaleimide (DTM) linker is demonstrated. Functionalisation is found to be reversible upon addition of a thiol-containing compound, glutathione, resulting in switchable surface properties including fluorescence and wettability, hence broadening the scope of applications.
A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones
Casta?eda, Lourdes,Wright, Zo? V.F.,Marculescu, Cristina,Tran, Trang M.,Chudasama, Vijay,Maruani, Antoine,Hull, Elizabeth A.,Nunes, Jo?o P.M.,Fitzmaurice, Richard J.,Smith, Mark E.B.,Jones, Lyn H.,Caddick, Stephen,Baker, James R.
, p. 3493 - 3495 (2013/07/05)
Bromomaleimides are useful building blocks in synthesis and powerful reagents for the selective chemical modification of proteins. A mild new synthesis of these reagents is described, along with the convenient transferability of the approach to dithiomale
