32774-53-1Relevant academic research and scientific papers
Conjugation-induced fluorescent labeling of proteins and polymers using dithiomaleimides
Robin, Mathew P.,Wilson, Paul,Mabire, Anne B.,Kiviaho, Jenny K.,Raymond, Jeffery E.,Haddleton, David M.,O'Reilly, Rachel K.
, p. 2875 - 2878 (2013)
Dithiomaleimides (DTMs) with alkyl substituents are shown to be a novel class of highly emissive fluorophores. Variable solubility and further functionalization can easily be tailored through the choice of N and S substituents. Inclusion of a DTM unit int
Reduction-responsive dithiomaleimide-based nanomedicine with high drug loading and FRET-indicated drug release
Wang, Hua,Xu, Ming,Xiong, Menghua,Cheng, Jianjun
, p. 4807 - 4810 (2015)
Dithiomaleimide-based camptothecin-containing nanoparticles are designed to have exceptionally high drug loading and are capable of reduction-responsive, FRET-indicated drug release.
Synthesis of New (Arylsulfanyl)maleimide Derivatives
Panov,Simonov, A. Yu.,Korolev
, p. 1847 - 1852 (2019)
Previously unknown 2-(arylsulfanyl)-3-hydroxymaleimide and 2-(arylsulfanyl)-3-chloromaleimide derivatives have been synthesized, and several synthetic approaches to 2-(arylamino)-3-(arylsulfanyl)-maleimides have been tested. The reactivities of 2-chloro-3-(4-methylphenylsulfanyl)maleimide and 2,3-bis(4-methylphenylsulfanyl)maleimide toward nitrogen and sulfur nucleophiles have been studied, and products of substitution of one or two arylsulfanyl groups have been obtained.
Di-substituted maleic amide linker for antibody drug conjugating and preparation method and use thereof
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Page/Page column 80; 81, (2021/04/28)
Provided in the present invention are a di-substituted maleic amide linker conjugated to an antibody and a preparation method and use thereof. In particular, the present invention conjugates a strongly cytotoxic active substance to a biomacromolecule thro
Reversible covalent linkage of functional molecules
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Page/Page column 59, (2016/04/26)
The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R1—H which comprises a first functional moiety of formula F1 to a second functional moiety of fo
Synthesis and antibacterial evaluation of some teicoplanin pseudoaglycon derivatives containing alkyl-and arylthiosubstituted maleimides
Csávás, Magdolna,Miskovics, Adrienn,Szcs, Zsolt,Rth, Erzsébet,Nagy, Zsolt L,Bereczki, Ilona,Herczeg, Mihály,Batta, Gyula,Nemes-Nikodém, éva,Ostorházi, Eszter,Rozgonyi, Ferenc,Borbás, Anikó,Herczegh, Pál
, p. 579 - 585 (2015/10/12)
Bis-Alkylthio maleimido derivatives have been prepared from teicoplanin pseudoaglycon by reaction of its primary amino group with N-ethoxycarbonyl bis-Alkylthiomaleimides. Some of the new derivatives displayed excellent antibacterial activity against resi
Development of a long acting human growth hormone analog suitable for once a week dosing
Palanki, Moorthy S.S.,Bhat, Abhijit,Bolanos, Ben,Brunel, Florence,Del Rosario, Joselyn,Dettling, Danielle,Horn, Mark,Lappe, Rodney,Preston, Ryan,Sievers, Annette,Stankovic, Nebojsa,Woodnut, Gary,Chen, Gang
, p. 402 - 406 (2013/02/23)
Human growth hormone was conjugated to a carrier aldolase antibody, using a novel linker by connecting a disulphide bond in growth hormone to a lysine-94 amine located on the Fab arm of the antibody. The resulting CovX body showed reduced affinity towards human growth hormone receptor, reduced cell-based activity, but improved pharmacodynamic properties. We have demonstrated that this CovX-body, given once a week, showed comparable activity as growth hormone given daily in an in vivo hypophysectomized rat model.
A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones
Casta?eda, Lourdes,Wright, Zo? V.F.,Marculescu, Cristina,Tran, Trang M.,Chudasama, Vijay,Maruani, Antoine,Hull, Elizabeth A.,Nunes, Jo?o P.M.,Fitzmaurice, Richard J.,Smith, Mark E.B.,Jones, Lyn H.,Caddick, Stephen,Baker, James R.
supporting information, p. 3493 - 3495 (2013/07/05)
Bromomaleimides are useful building blocks in synthesis and powerful reagents for the selective chemical modification of proteins. A mild new synthesis of these reagents is described, along with the convenient transferability of the approach to dithiomale
Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides
Jones, Mathew W.,Strickland, Rachel A.,Schumacher, Felix F.,Caddick, Stephen,Baker, James. R.,Gibson, Matthew I.,Haddleton, David M.
supporting information; experimental part, p. 4064 - 4066 (2012/06/01)
The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for sal
