1442461-60-0

Basic information

• Product Name: C₁₉H₁₆O₇
• Synonyms: C₁₉H₁₆O₇
• CAS NO: 1442461-60-0
• Molecular Weight: 356.332
• Mol File: 1442461-60-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₆O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₆O₇(1442461-60-0)
• EPA Substance Registry System: C₁₉H₁₆O₇(1442461-60-0)

Safety Data

• Hazardous Substances Data: 1442461-60-0(Hazardous Substances Data)

Upstream product

• 1442461-54-2 C₂₅H₂₇BO₇ 
• 1442461-55-3 ethyl 7-((4-methoxybenzyl)oxy)-2-oxo-2H-chromene-3-carboxylate 
• 1442461-56-4 C₂₁H₂₀O₇ 
• 105837-04-5 7-bromo-2-oxo-2H-chromene-3-carboxylic acid ethyl ester 
• 22532-62-3 4-bromosalicylaldehyde 
• 21852-32-4 4-bromomethyl-1,2-dimethoxybenzene 
• 6093-71-6 7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester 
• 1442461-70-2 C₁₈H₂₁BO₆ 

Relevant articles and documents

A versatile long-wavelength-absorbing scaffold for Eu-based responsive probes

Coumarin-sensitized, long-wavelength-absorbing luminescent Eu III-complexes have been synthesized and characterized. The lanthanide binding site consists of a cyclen-based chelating framework that is attached through a short linker to a 7-hydroxycoumarin, a 7-B(OH)2-coumarin, a 7-O-(4-pinacolatoboronbenzyl)-coumarin or a 7-O-(4-methoxybenzyl)-coumarin. The syntheses are straightforward, use readily available building blocks, and proceed through a small number of high-yielding steps. The sensitivity of coumarin photophysics to the 7-substituent enables modulation of the antenna-absorption properties, and thus the lanthanide excitation spectrum. Reactions of the boronate-based functionalities (cages) with H2O 2 yielded the corresponding 7-hydroxycoumarin species. The same species was produced with peroxynitrite in a ×106-10 7-fold faster reaction. Both reactions resulted in the emergence of a strong ≈407 nm excitation band, with concomitant decrease of the 366 nm band of the caged probe. In aqueous solution the methoxybenzyl caged Eu-complex was quenched by ONOO-. We have shown that preliminary screening of simple coumarin-based antennae through UV/Vis absorption spectroscopy is possible as the changes in absorption profile translate with good fidelity to changes in EuIII-excitation profile in the fully elaborated complex. Taken together, our results show that the 7-hydroxycoumarin antenna is a viable scaffold for the construction of turn-on and ratiometric luminescent probes. A visible change: Eu complexes can be rendered analyte responsive by exploiting the sensitivity of a coumarin antenna to the nature of the 7-substituent (see figure). A boronate switch installed in the 7-position afforded complexes that responded rapidly to μM concentrations of peroxynitrite; the product of this reaction being the corresponding phenol. The analogous reaction with H 2O2 proceeds at a significantly lower rate. As the reaction shifts the absorption to longer wavelengths, the construction of ratiometric probes is possible. Copyright