1443215-61-9

Upstream product

• 51594-59-3 1-(4-fluorophenyl)-2-propen-1-one 
• 64-19-7 acetic acid 
• 1384259-78-2 3-(4-fluorophenyl)prop-2-yn-1-yl acetate 
• 18826-59-0 1-(4-fluorophenyl)-prop-1-yne 
• 3375-31-3 palladium diacetate 
• 456-03-1 1-(4-fluorophenyl)propan-1-one 
• 108-24-7 acetic anhydride 
• 10557-24-1 1-(4-fluoro-phenyl)-propane-1,2-dione 

Relevant academic research and scientific papers

A General Method for α-Oxyacylation of Vinyl Ketones Using Koser's Reagent

A direct general method for the preparation of α-oxyacylated vinyl ketones using Koser's hypervalent iodine reagent is reported. A variety of acyloxy groups from long-chain aliphatic, aromatic, α,β-unsaturated carboxylic acids have been installed efficiently for the first time. The oxyacylated adducts were used for the preparation of densely functionalized chiral δ-lactones and cyclopentenes using carbene organocatalysis.

An Unprecedented (Semi)Favorskii rearrangement. evidence for the 2-(Acyloxy)cyclopropanones

Discovery and development of an unprecedented (semi)Favorskii rearrangement has been reported. The intermediacy of structurally singular (acyloxy)cyclopropanones has been unraveled by fruitful control experiments including a crossover experiment. This class of cyclopropanones is found to be inert for classical Favorskii functionalization and preferably undergoes a decycloisomerization (ring-chain valence tautomerism) to α-(acyloxy)enones. A cascade conversion of α,α-diiodo-α′-acetoxyketones to (acyloxy)cyclopropanones via α-iodo-α′-acetoxyketones has been achieved by the synchronous dual basicity (Lewis and Br?nsted) of amines. The overall process is found to be very general for diverse substrates and highly efficient.

Pd-Catalyzed oxidative isomerization of propargylic acetates: Highly efficient access to α-acetoxyenones: Via alkenyl Csp2-O bond-forming reductive elimination from PdIV

A Pd(ii)/(iv)-catalyzed oxidative isomerization of propargylic acetates developed for the synthesis of polysubstituted alkenyl acetates is described. The reductive elimination of alkenyl Csp2-OAc bonds from PdIV intermediates is achieved. Mechanistic studies indicate that the reaction mechanism consists of trans acetoxypalladation of a triple bond, isomerization, oxidative addition with PhI(OAc)2 and alkenyl C-OAc bond reductive elimination.

Synthesis method of polysubstituted alpha-acetoxyl-alpha, beta-ketenes compounds

The invention discloses a synthesis method of polysubstituted alpha-acetoxyl-alpha, beta-ketenes compounds. Propargylacetic ester is used as raw materials; under the effect of a metal palladium catalyst, through isomerization and alkenyl C-OAc bond reduct

Palladium-Catalyzed Oxidative Synthesis of α-Acetoxylated Enones from Alkynes

We report a palladium-catalyzed oxidative functionalization of alkynes to generate α-acetoxylated enones in one step. A range of functional groups are well-tolerated in this reaction. Mechanistic studies, including the use of 18O-labeled DMSO,

A simple synthetic route to enantiopure α-hydroxy ketone derivatives by asymmetric hydrogenation

High enantioselectivities (up to 99% ee) have been observed for the catalytic asymmetric hydrogenation of the α-ketone enol acetates. DuanPhos has been proved to be the most effective ligand for this reaction. The high yield and enantioselectivity of the asymmetric hydrogenation of the α-ketone enol acetates represents a feasible synthetic route to important pharmaceutical building blocks: α-hydroxy ketones. Copyright