10557-24-1

Usage

Physical state

Pale yellow liquid

Odor

Sweet, fruity

Usage

Flavoring agent in the food industry

Application

Intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Hazardous nature

Yes, considered a hazardous substance

Health risks

Irritation to skin, eyes, and respiratory system

Safety precautions

Necessary when handling and storing the chemical

Upstream product

• 395-26-6 HONC(CH₃)C(C₆H₄F)O 
• 928840-61-3 2-methyl-3-(4-fluorophenyl)-1,3-propane diol 
• 405-99-2 para-fluorostyrene 
• 75-52-5 nitromethane 
• 456-03-1 1-(4-fluorophenyl)propan-1-one 
• 32763-20-5 1-(4-Fluoro-phenyl)-2,2-dimethoxy-propan-1-one 

Downstream Products

• 1572247-69-8 6,7-Dichloro-2-(4-fluorophenyl)-3-methylquinoxaline 
• 1443215-61-9 3-(4-fluorophenyl)-3-oxoprop-1-en-2-yl acetate 
• 1443215-65-3 (R)-1-(4-fluorophenyl)-1-oxopropan-2-yl acetate 
• 1279712-73-0 N-(3-(4-fluorophenyl)-3-oxoprop-1-en-2-yl)acetamide 
• 889859-37-4 2-(4-fluorophenyl)-3-methylquinoxaline 

Relevant academic research and scientific papers

First representatives of functionalized D-π-A chromophores containing a tunable hydroxytricyanopyrrole (HTCP) acceptor and: N, N -disubstituted aminophenyl donor

The first representatives of D-π-A chromophores containing a hydroxytricyanopyrrole (HTCP) acceptor and N,N-disubstituted aminophenyl donor were synthesized. The obtained molecules include reactive NH- and OH-fragments allowing the photophysical propertie

A simple synthetic route to enantiopure α-hydroxy ketone derivatives by asymmetric hydrogenation

High enantioselectivities (up to 99% ee) have been observed for the catalytic asymmetric hydrogenation of the α-ketone enol acetates. DuanPhos has been proved to be the most effective ligand for this reaction. The high yield and enantioselectivity of the asymmetric hydrogenation of the α-ketone enol acetates represents a feasible synthetic route to important pharmaceutical building blocks: α-hydroxy ketones. Copyright

A rapid synthesis of quinoxalines starting from ketones

A fast and general synthesis of quinoxalines, performed in two stages or as a one-pot reaction, starting from ketones via their α-hydroxylimino ketone derivatives, and condensation of the latter with 1,2-diaminobenzene under microwave irradiation, is described.

New synthetic strategy for high-enantiopurity N-protected α-amino ketones and their derivatives by asymmetric hydrogenation

Asymmetric hydrogenation of α-dehydroamino ketones catalyzed by a rhodium-chiral phosphorus ligand complex (up to 99% ee, 1000 TON), represents an efficient approach to chiral α-amino ketones. The reduction of α-amino ketones catalyzed by palladium on carbon (Pd/C) leads to amphetamine precursors with quantitative yield and no significant enantioselectivity loss.

Luminescence comparison of iridium(III) complexes containing symmetric vs. asymmetric quinolinate ligands

We have focused our research on development of the iridium complexes, especially with respect to blue and red emission for OLED. Previously, we prepared bis-[2,3-bis(4-fluorophenyl)quinoxalinato]iridium(acetylacetonate) [Ir(2,3-dpqx-F2)2/

Palladium-catalyzed carbonation-diketonization of terminal aromatic alkenes via carbon-nitrogen bond cleavage for the synthesis of 1,2-diketones

A palladium-catalyzed carbonation-diketonization reaction of terminal alkenes via carbon-nitrogen bond cleavage under an atmosphere of oxygen has been developed. A series of 1,2-diketones were readily prepared from the reaction of aromatic terminal alkenes with nitroalkanes.

2-Iodoxybenzoic acid mediated facile conversion of 1,3-diols to 1,2-diketones by oxidative cleavage of the C-C bond

1,3-Diols undergo smooth oxidative cleavage of the C-C bond in the presence of 2-iodoxybenzoic acid (IBX) affording 1,2-diketones in excellent yields under mild conditions. Georg Thieme Verlag Stuttgart.

Reaction of Z isomers of alkylaromatic 1,2-hydroxylamino oximes with 1,2-diketones

The reactions of Z isomers of alkylaromatic 1,2-hydroxylamino oximes containing the hydroxylamino group at the primary or secondary carbon atom with diacetyl afford 6-acetyl-5,6-dihydro-4H-1,2,5-oxadiazines. The reactions of these compounds with alkylaromatic 1,2-diketones produce N-substituted α-aroylnitrones or 6-aroyl-5,6-dihydro-4H-1,2,5-oxadiazines or, alternatively, their tautomeric mixtures.

A Highly Efficient Ruthenium-Catalyzed Rearrangement of α,β-Epoxyketones to 1,2-Diketones

TpRuPPh3(CH3CN)2PF6 catalyzed the efficient rearrangement of α,β-epoxyketones to 1,2-diketones. Unlike a previously reported iron catalyst, the reaction in this case is applicable not only to 1,2-disubstituted epoxides but also to mono- and trisubstituted epoxides and tolerates oxygen functionalities. The sterically crowded and highly basic tris(1-pyrazolyl)borate (Tp) ligand of the ruthenium catalyst might account for its high selectivity toward 1,2-diketone rather than 1,3-diketone.

REACTIONS OF 1-ARYL-2,2-DICHLORO-1-PROPANONES. II. REACTION OF 1-(4-R-PHENYL)-2,2-DICHLORO-1-PROPANONES WITH SOME NUCLEOPHILES

The reactions of 1-(4-R-phenyl)-2,2-dichloro-1-propanones with alkali-metal alkoxides and certain amines (morpholine, piperidine) and also their conversion into α-diketones were studied.By IR and mass spectrometry it was shown that the methoxylation of these compounds with sodium methoxide leads to the formation of the products from direct substitution of the halogen atoms by methoxyl groups.The kinetics of methoxylation are described by a second-order equation, and a Hammett correlation with a positive reaction constant is observed in the rate constants.