1443215-65-3Relevant academic research and scientific papers
Hypervalent Iodine(III)-Catalysed Enantioselective α-Acetoxylation of Ketones
Hokamp, Tobias,Wirth, Thomas
supporting information, p. 10417 - 10421 (2020/07/24)
An enantioselective catalytic synthesis of α-acetoxylated ketones through I(I)/I(III) catalysis using a resorcinol/lactamide-based chiral iodoarene is reported. Catalyst turnover by in situ generation of the active iodine(III) derivative is achieved by oxidation with mCPBA in the presence of acetic acid. The prior transformation of ketones to easily accessible acetyl enol ethers is beneficial and yields up to 97 percent with enantioselectivities up to 88 percent ee are obtained using only low catalyst loadings of only 5 mol percent under mild reaction conditions.
A simple synthetic route to enantiopure α-hydroxy ketone derivatives by asymmetric hydrogenation
Sun, Tian,Zhang, Xumu
, p. 3211 - 3215 (2013/01/15)
High enantioselectivities (up to 99% ee) have been observed for the catalytic asymmetric hydrogenation of the α-ketone enol acetates. DuanPhos has been proved to be the most effective ligand for this reaction. The high yield and enantioselectivity of the asymmetric hydrogenation of the α-ketone enol acetates represents a feasible synthetic route to important pharmaceutical building blocks: α-hydroxy ketones. Copyright
