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Relevant academic research and scientific papers

A co-operative effect of visible light photo-catalysis and CoFe2O4 nanoparticles for green synthesis of furans in water

A novel approach to poly-functionalized furan synthesis is disclosed via oxidative decarboxylative [3+2] cycloaddition using co-operative catalysis by visible light and CoFe2O4 nanoparticles under ambient reaction conditions with water as a solvent. Although the reported method is efficient without catalyst in the presence of visible light (70% yield in 4 h at rt), the use of catalyst not only increases the yield (91%) but also accelerates the conversion rate (2 h at rt).

A pharmaceutical intermediates substituted furyl synthetic method of compound

The invention relates to a synthetic method for a polysubstituted furan compound as shown in the following formula (III). The synthetic method comprises the following steps: under the air atmosphere, in the presence of a catalyst, an oxidizing agent, an additive and soda, stirring a compound as shown in a formula (I) of the description and a compound as shown in a formula (II) of the description in an organic solvent at the temperature of 60-80 DEG C to enable the mixture to react for 7-10 hours, after the reaction, performing after-treatment to obtain the compound as shown in the formula (III) of the description, wherein each of R1and R2 is independently selected from H or C1-C6 alkyl; R3 is selected from H, C1-C6 alkyl, C1-C6 alkoxy or halogen; X is a halogen. According to the method, through the use of a suitable substrate as well as selection and synergism of the catalyst, the oxidizing agent, the additive, soda and the organic solvent, a high-yield target product can be obtained; the synthetic method has an excellent application prospect and a wide industrial production potentiality in the technical field of drug intermediate synthesis.

Copper-Catalyzed Regioselective Synthesis of Multisubstituted Furans by Coupling between Ketones and Aromatic Olefins

A regioselective synthesis of multisubstituted furan derivatives has been developed via Cu(II)-catalyzed intermolecular annulation of aryl ketones with a wide range of aromatic olefins under ambient air in good yields. This protocol is applicable to both cyclic and acyclic aryl ketones.

Domino Radical Addition/Oxidation Sequence with Photocatalysis: One-Pot Synthesis of Polysubstituted Furans from α-Chloro-Alkyl Ketones and Styrenes

A new domino reaction has been developed that allows the combination of styrenes and α-alkyl ketone radicals to afford a wide array of polysubstituted furans in good to excellent yields under mild and simple reaction conditions. The key to success of this novel protocol is the use of photocatalyst fac-Ir(ppy)3and oxidant K2S2O8. Mechanistic studies by a radical scavenger and photoluminescence quenching suggest that a radical addition/oxidation pathway is operable.

Regioselective Synthesis of Multisubstituted Furans via Copper-Mediated Coupling between Ketones and β-Nitrostyrenes

A copper-mediated intermolecular annulation of alkyl ketones and β-nitrostyrenes has been developed for the regioselective synthesis of multisubstituted furan derivatives in good yields. This protocol is applicable to both cyclic and acyclic ketones. (Che

Copper-catalyzed regioselective synthesis of furan via tandem cycloaddition of ketone with an unsaturated carboxylic acid under air

A catalytic decarboxylative annulation has been developed for the regioselective synthesis of trisubstituted furans by the cycloaddition of ketones with α,β-unsaturated carboxylic acids under ambient air. A library of furan derivatives were obtained in good yields from the readily available substrates in the combination of a catalytic amount of Cu-salt and a stoichiometric amount of water. Water plays a crucial role in this catalytic transformation. This journal is

Synthesis of polysubstituted furans via copper-mediated annulation of alkyl ketones with α,β-unsaturated carboxylic acids

A novel copper-mediated annulation of alkyl ketones with α,β-unsaturated carboxylic acids has been accomplished. This reaction provides a facile and regio-defined method for the synthesis of 2,3,5-trisubstituted furans from simple chemical reagents.