1443535-38-3Relevant academic research and scientific papers
Comparison of the full-length and 152~528 truncate of human cyclic nucleotide phosphodiesterase 4b2 for the characterization of inhibitors
Zhang, Xiang,He, Shu,Hu, Xiaolei,Wu, Jing,Li, Xinpeng,Liao, Fei,Yang, Xiaolan
, p. 49 - 58 (2019/08/06)
Aim and Objective: Human full-length cyclic nucleotide phosphodiesterase isozyme 4B2 (hPDE4B2) as the target for screening and characterizing inhibitors suffers from low activity yield and the coexistence of two conformational states bearing different aff
From paracetamol to rolipram and derivatives: Application of deacetylation-diazotation sequences and palladium-catalyzed matsuda-heck reaction
Schmidt, Bernd,Elizarov, Nelli,Berger, Rene,Petersen, Monibh.
supporting information, p. 1174 - 1180 (2013/06/05)
A six-step synthesis of the antidepressant rolipram from the popular analgetic 4-acetamidophenol (paracetamol) is described. The steps include oxidative functionalization of the aromatic core, diazonium salt formation via deacetylation-diazotation, Matsuda-Heck reaction, conjugate addition of nitromethane, and hydrogenative cyclization. Georg Thieme Verlag Stuttgart · New York.
