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1443749-22-1

(2'S,3R,4'S,5'R)-6-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1S,3R)-3-hydroxycyclopentyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • (2'S,3R,4'S,5'R)-6-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1S,3R)-3-hydroxycyclopentyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide

    Cas No: 1443749-22-1

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  • (2'S,3R,4'S,5'R)-6-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1S,3R)-3-hydroxycyclopentyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide

    Cas No: 1443749-22-1

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  • 1443749-22-1 Structure

  • Basic information

    1. Product Name: (2'S,3R,4'S,5'R)-6-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1S,3R)-3-hydroxycyclopentyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide
    2. Synonyms:
    3. CAS NO:1443749-22-1
    4. Molecular Formula:
    5. Molecular Weight: 548.485
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1443749-22-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2'S,3R,4'S,5'R)-6-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1S,3R)-3-hydroxycyclopentyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2'S,3R,4'S,5'R)-6-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1S,3R)-3-hydroxycyclopentyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide(1443749-22-1)
    11. EPA Substance Registry System: (2'S,3R,4'S,5'R)-6-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1S,3R)-3-hydroxycyclopentyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide(1443749-22-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1443749-22-1(Hazardous Substances Data)

1443749-22-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1443749-22-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,3,7,4 and 9 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1443749-22:
(9*1)+(8*4)+(7*4)+(6*3)+(5*7)+(4*4)+(3*9)+(2*2)+(1*2)=171
171 % 10 = 1
So 1443749-22-1 is a valid CAS Registry Number.

1443749-22-1Downstream Products

1443749-22-1Relevant articles and documents

A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice

Zhao, Yujun,Yu, Shanghai,Sun, Wei,Liu, Liu,Lu, Jianfeng,McEachern, Donna,Shargary, Sanjeev,Bernard, Denzil,Li, Xiaoqin,Zhao, Ting,Zou, Peng,Sun, Duxin,Wang, Shaomeng

, p. 5553 - 5561 (2013/07/26)

We previously reported the discovery of a class of spirooxindoles as potent and selective small-molecule inhibitors of the MDM2-p53 interaction (MDM2 inhibitors). We report herein our efforts to improve their pharmacokinetic properties and in vivo antitumor activity. Our efforts led to the identification of 9 (MI-888) as a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. Compound 9 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.

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