1443997-83-8

Basic information

• Product Name: C₃₆H₂₈O₉
• Synonyms: C₃₆H₂₈O₉
• CAS NO: 1443997-83-8
• Molecular Weight: 604.613
• Mol File: 1443997-83-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₆H₂₈O₉(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₂₈O₉(1443997-83-8)
• EPA Substance Registry System: C₃₆H₂₈O₉(1443997-83-8)

Safety Data

• Hazardous Substances Data: 1443997-83-8(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 157037-56-4 1,3,5-tri-O-benzoyl-2-oxo-α-D-erythro-pentofuranose 
• 69339-86-2 1,2,3,5-tetra-O-benzoyl-α-D-ribofuranoside 
• 16466-97-0 1-propynylmagnesium bromide 

Relevant articles and documents

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

To identify a potent and selective nucleoside inhibitor of dengue virus RNA-dependent RNA polymerase, a series of 2′- and/or 4′-ribose sugar modified uridine nucleoside phosphoramidate prodrugs and their corresponding triphosphates were synthesized and evaluated. Replacement of 2′-OH with 2′-F led to be a poor substrate for both dengue virus and human mitochondrial RNA polymerases. Instead of 2′-fluorination, the introduction of fluorine at the ribose 4′-position was found not to affect the inhibition of the dengue virus polymerase with a reduction in uptake by mitochondrial RNA polymerase. 2′-C-ethynyl-4′-F-uridine phosphoramidate prodrug displayed potent anti-dengue virus activity in the primary human peripheral blood mononuclear cell-based assay with no significant cytotoxicity in human hepatocellular liver carcinoma cell lines and no mitochondrial toxicity in the cell-based assay using human prostate cancer cell lines.