14445-54-6

Basic information

• Product Name: L-isoleucinamide
• Synonyms: L-Isoleucinamide; pentanamide, 2-amino-3-methyl-, (2S,3S)-
• CAS NO: 14445-54-6
• Molecular Formula: C₆H₁₄N₂O
• Molecular Weight: 130.1882
• Mol File: 14445-54-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 250.9°C at 760 mmHg
• Flash Point: 105.6°C
• Density: 0.98g/cm³
• Vapor Pressure: 0.0211mmHg at 25°C
• Refractive Index: 1.467
• CAS DataBase Reference: L-isoleucinamide(CAS DataBase Reference)
• NIST Chemistry Reference: L-isoleucinamide(14445-54-6)
• EPA Substance Registry System: L-isoleucinamide(14445-54-6)

Safety Data

• Hazardous Substances Data: 14445-54-6(Hazardous Substances Data)

Upstream product

• 71989-23-6 Fmoc-Ile-OH 
• 94888-34-3 tert-butyl ((2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl)carbamate 
• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 
• 47174-55-0 Z(OMe)-Ile-OH 
• 10466-56-5 L-isoleucine amide hydrochloride 
• 329686-65-9 (2S,3S)-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanamide 
• 89762-65-2 Z(OMe)-Ile-NH₂ 
• 2577-46-0 L-isoleucine methyl ester 

Downstream Products

• 1350980-58-3 N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-L-isoleucine amide 
• 1283599-80-3 C₄₂H₃₅N₃O₇S 
• 89762-60-7 Z(OMe)-Leu-Glu(OBzl)-Ser-Leu-Ile-NH₂ 
• 89762-72-1 Boc-Glu(OBzl)-Ser-Leu-Ile-NH₂ 
• 89821-31-8 H-Leu-Glu(OBzl)-Ser-Leu-Ile-NH₂ 
• 89762-73-2 H-Glu(OBzl)-Ser-Leu-Ile-NH₂ 
• 89762-69-6 Z(OMe)-Ser-Leu-Ile-NH₂ 
• 82985-42-0 Z-Glu(OBu-t)-Ser(Bu-t)-Leu-Ile-NH₂ 
• 82996-82-5 Z-Ser(Bu-t)-Leu-Ile-NH₂ 
• 130985-91-0 salicylidene-L-isoleucinamide 
• 116857-42-2 Z(OMe)-Leu-Leu-Asp(OBzl)-Thr-Ile-NH₂ 
• 116857-50-2 Z(OMe)-Asp(OBzl)-Thr-Ile-NH₂ 
• 92265-08-2 Z(OMe)-Met(O)-Glu(OBzl)-Ile-Ile-NH₂ 
• 95878-50-5 Z(OMe)-Glu(OBzl)-Ile-Ile-NH₂ 

Relevant articles and documents

HEMIAMINAL-TAG FOR PROTEIN LABELING AND PURIFICATION

The invention pertains to the synthesis, isolation, and characterization of hemiaminal for selective labeling of peptides, proteins, antibodies, and organic fragments with -C(=0) CH2NH2 and derivatives with -CH2NH2 group over -C(=0) CHRNH2 group (where R≠H). The invention also pertains to the method of single-site immobilization of proteins through N-terminus Gly on solid phase. The invention includes late-stage tagging of N-terminus Gly with an affinity tag, 19F NMR probe, and a fluorophore and a method for metal-free protein purification and isolation of analytically pure proteins.

Carbamates of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxicity and cell cycle effects

In an attempt to generate compounds with superior bioactivity and reduced toxicity, 12 carbamates of 4′-demethyl-4-deoxypodophyllotoxin, N-(1-oxyl-4′-demethyl- 4-deoxypodophyllic)-α-amino acids amides, were synthesized and evaluated for antiproliferative activity and cell cycle effects. These synthesized compounds proved to be more hydrophilic, as well as improved or comparable in vitro cytotoxicities against four cell lines (A-549, HeLa, SiHa, and HL-60) compared with either parent DPT or anti-cancer drug VP-16. Furthermore, flow cytometric analysis exhibited that N-(1-oxyl-4′- demethyl-4-deoxypodophyllic)-d-α-methine amide (15f) induced cell cycle arrest in the G2/M phase in A-549 cells.

Studies on peptides. CXXIII. Preparations of nine peptide fragments for the synthesis of human corticotropin releasing factor (hCRF)

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