14445-99-9

Upstream product

• 87-69-4 L-Tartaric acid 
• 108-91-8 cyclohexylamine 
• 87-91-2 diethyl (2R,3R)-tartrate 
• 608-68-4 dimethyl L-tartrate 

Downstream Products

• 51737-90-7 N-Cyclohexyl-2-oxo-acetamide 
• 395644-86-7 N-cyclohexyl-2-hydroxy-3-aminobutyric amide 
• 395644-83-4 N-cyclohexyl-2-hydroxy-3-nitrobutyric amide 
• 460048-61-7 formic acid 1-cyclohexylcarbamoyl-2-isocyano-propyl ester 
• 460049-37-0 N-cyclohexyl-2-formyloxy-3-formamidobutyric amide 
• 460048-69-5 2-[(2-Acetylamino-acetyl)-(3-methyl-butyl)-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide 
• 460048-65-1 2-[(2-Acetylamino-acetyl)-benzyl-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide 
• 460048-67-3 3-{2-[acetylaminoacetyl-(3-methyl-butyl)-amino]-3-phenyl-propionylamino}-N-cyclohexyl-2-hydroxy-butyramide 
• 460048-63-9 3-[2-(acetylaminoacetyl-benzyl-amino)-3-phenyl-propionylamino]-N-cyclohexyl-2-hydroxy-butyramide 
• 460336-92-9 2-[((S)-2-Acetylamino-3-phenyl-propionyl)-(3-methyl-butyl)-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide 
• 460336-88-3 2-[((S)-2-Acetylamino-3-phenyl-propionyl)-benzyl-amino]-4-methyl-pentanoic acid (2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethyl)-amide 
• 460336-90-7 3-{2-[(2-acetylamino-3-phenyl-propionyl)-(3-methyl-butyl)-amino]-3-phenyl-propionylamino}-N-cyclohexyl-2-hydroxy-butyramide 
• 460336-86-1 3-{2-[(2-acetylamino-3-phenyl-propionyl)-benzyl-amino]-3-phenyl-propionylamino}-N-cyclohexyl-2-hydroxy-butyramide 
• 460048-81-1 N-benzyl-N'-{[[1-(2-cyclohexylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-succinamide 

Relevant academic research and scientific papers

Solvent-free synthesis of tartramides under microwave activation

The preparation of aliphatic, aromatic or functionalized tartramides directly from tartaric acid and amines under microwave activation is described. The inexpensive, solvent free and fast reaction conditions are the important features of the procedure.

ALPHA-D-GALACTOPYRANOSIDE DERIVATIVES

The present invention relates to compounds of Formula (I) wherein Ar1, R1 and R2 are as described in the description, and A is 4,5-dihydroisoxazole-3,5-diyl, imidazolidin-4-one-l,3-diyl, oxazol-2- one-3,5-diyl and oxazolidine-2-one-3,5-diyl, l,2,3-triazole-l,4-diyl, isoxazole-3,5-diyl, imidazole-1, 4-diyl, and isothiazole-3,5-diyl; and their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.

Synthesis of a peptidomimetic HCMV protease inhibitor library

The human cytomegalovirus (HCMV) protease catalyzes the maturational process of the herpes virus assembly protein and plays a key role during the manufacture of viral capsid, and so is an attractive target for potential anti-herpes-virus agents with novel structures and new mechanisms. In this work, a peptidomimetic skeleton was designed and a chemical library containing 32 compounds with different substitutions on the skeleton was prepared by the oxidation of a precursor library, which was constructed from four types of building blocks: 4 carboxylic acids, 2 amines, 2 aldehydes and 2 isocyanides, based on multicomponent condensation following liquid phase strategies. The syntheses of the key building block isocyanides are presented.