1444611-58-8

Basic information

• Product Name: 5-chloro-3,4-diphenylisoquinolin-1(2H)-one
• Synonyms: 5-chloro-3,4-diphenylisoquinolin-1(2H)-one
• CAS NO: 1444611-58-8
• Molecular Weight: 331.801
• Mol File: 1444611-58-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-chloro-3,4-diphenylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3,4-diphenylisoquinolin-1(2H)-one(1444611-58-8)
• EPA Substance Registry System: 5-chloro-3,4-diphenylisoquinolin-1(2H)-one(1444611-58-8)

Safety Data

• Hazardous Substances Data: 1444611-58-8(Hazardous Substances Data)

Upstream product

• 64648-18-6 N-methoxy(m-chloro)benzamide 
• 501-65-5 diphenyl acetylene 
• 4070-53-5 3-chloro-N-hydroxybenzamide 
• 766-84-7 3-chloro-benzonitrile 

Relevant articles and documents

Redox-Neutral [4 + 2] Annulation of N-Methoxybenzamides with Alkynes Enabled by an Osmium(II)/HOAc Catalytic System

By making use of a direct C-H activation strategy, an efficient osmium(II)-catalyzed redox-neutral [4 + 2] annulation of N-methoxybenzamides with alkynes has been accomplished. Computational and experimental studies revealed that such transformation leading to the synthesis of the isoquinolone core might follow an Os(II)-Os(IV)-Os(II) catalytic pathway, in which an unusual HOAc-assisted oxidative addition of osmium(II) into the N-O bond to generate the osmium(IV) species was involved as one of the key transition states. Further exploration of divergent C-H activation reaction modes enabled by the osmium(II) catalyst has also been exemplified for one-pot assembly of other either linear or cyclic products.

Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to isoquinolones

The oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes in the presence of a catalytic amount of [{RuCl2(p-cymene)} 2], Cu(OAc)2·H2O and KPF6 in acetic acid under air gave isoquinolones in good to excellent yields.