64648-18-6

Basic information

• Product Name: Benzamide, 3-chloro-N-methoxy-
• CAS NO: 64648-18-6
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Mol File: 64648-18-6.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzamide, 3-chloro-N-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 3-chloro-N-methoxy-(64648-18-6)
• EPA Substance Registry System: Benzamide, 3-chloro-N-methoxy-(64648-18-6)

Safety Data

• Hazardous Substances Data: 64648-18-6(Hazardous Substances Data)

Upstream product

• 593-56-6 N-methoxylamine hydrochloride 
• 618-46-2 m-Chlorobenzoyl chloride 
• 535-80-8 3-chlorobenzoate 
• 67-62-9 O-Methylhydroxylamin 

Downstream Products

• 1364511-71-6 7-chloro-2-methoxy-3,4-diphenylisoquinolin-1(2H)-one 
• 22868-29-7 2‐(3‐chlorophenyl)benzo[d]oxazole 
• 1428432-42-1 7-chloro-3,4-diphenylisoquinolin-1(2H)-one 
• 1456693-94-9 6-chloro-3-hydroxy-2-methoxy-3-phenylisoindolin-1-one 
• 1581719-92-7 5-chloro-N-methoxy-2-((triisopropylsilyl)ethynyl)benzamide 
• 131002-05-6 5-chloro-2-ethenylbenzamide 

Relevant articles and documents

Isoindolinone synthesis through Rh/Cu-catalyzed oxidative C-H/N-H annulation of N -methoxy benzamides with saturated ketones

The synthesis of isoindolinones from N-methoxy benzamides and saturated ketones via a bimetallic tandem catalytic annulation has been accomplished. The reaction is catalyzed by a Rh/Cu-cocatalytic system and proceeds via the combination of Cu-catalyzed de

Selective mono-alkylation of N-methoxybenzamides

We report our latest discovery of norbornene derivative modulated highly mono-selective ortho-C-H activation alkylation reactions on arenes bearing simple mono-dentate coordinating groups. The reaction features the use of readily available benzamides and alkyl halides. During the study, we prepared 30 mono-alkylated aryl amides in good yields with good mono-selectivity. We have also demonstrated that structurally rigid alkenes such as norbornene and its derivatives are a good class of ligand and could be used for future direct C-H functionalizations. The utilization of norbornene type ligands for assistance in C-H activation processes has opened a new window for future molecular design using direct C-H functionalization strategies.

Rh-Catalyzed annulations of: N -methoxybenzamides with ketenimines: Synthesis of 3-aminoisoindolinones and 3-diarylmethyleneisoindolinones with strong aggregation induced emission properties

Rhodium-catalyzed C-H activation/annulation reactions of ketenimines with N-methoxybenzamides furnished 3-aminoisoindolin-1-ones and 3-(diarylmethylene)isoindolin-1-ones. The synthesized 3-(diarylmethylene)isoindolin-1-ones exhibited aggregation induced emissions in aqueous tetrahydrofuran solution and strong green-yellow emissions in solids.