1444617-08-6

Basic information

• Product Name: C₂₆H₁₉NO₆
• CAS NO: 1444617-08-6
• Molecular Weight: 441.44
• Mol File: 1444617-08-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₁₉NO₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₁₉NO₆(1444617-08-6)
• EPA Substance Registry System: C₂₆H₁₉NO₆(1444617-08-6)

Safety Data

• Hazardous Substances Data: 1444617-08-6(Hazardous Substances Data)

Upstream product

• 14548-46-0 4-Benzoylpyridine 
• 115787-50-3 5-(2-bromoacetyl)-2-hydroxybenzaldehyde 
• 623-47-2 propynoic acid ethyl ester 

Relevant articles and documents

Indolizine derivatives as HIV-1 VIF-elonginc interaction inhibitors

Compound 1 (VEC-5) was identified as a potent small-molecular HIV-1 viron infectivity factor inhibitor that targets the viron infectivity factor-ElonginC interaction. A structure-activity relationship study was carried out to develop compounds with improved efficacy against HIV-1 and 49 indolizine derivatives of three categories were designed and synthesized. We found that five compounds exhibited promising anti-HIV-1 activity, and the most active compound 2g had an IC50 value of 11.0 μm. These results provide new information to develop highly potent small-molecule HIV-1 viron infectivity factor inhibitors.