144477-79-2

Basic information

• Product Name: 2-Butenenitrile,3-(4-fluorophenyl)-,(Z)-(9CI)
• Synonyms: 2-Butenenitrile,3-(4-fluorophenyl)-,(Z)-(9CI)
• CAS NO: 144477-79-2
• Molecular Formula: C₁₀H₈FN
• Molecular Weight: 161.18
• Product Categories: HALIDE
• Mol File: 144477-79-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Butenenitrile,3-(4-fluorophenyl)-,(Z)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenenitrile,3-(4-fluorophenyl)-,(Z)-(9CI)(144477-79-2)
• EPA Substance Registry System: 2-Butenenitrile,3-(4-fluorophenyl)-,(Z)-(9CI)(144477-79-2)

Safety Data

• Hazardous Substances Data: 144477-79-2(Hazardous Substances Data)

Upstream product

• 143589-42-8 3-(4'-fluorophenyl)cyclobutan-1-one 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 75-05-8 acetonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 350-40-3 2-(4-fluorophenyl)-1-propene 

Relevant articles and documents

Palladium-catalyzed synthesis of nitriles from N-phthaloyl hydrazones

The Pd-catalyzed transformation of N-phthaloyl hydrazones into nitriles involving the cleavage of an N-N bond is reported. The use of N-heterocyclic carbene as a ligand is essential for the success of the reaction. N-Phthaloyl hydrazones prepared from aromatic aldehydes or cyclobutanones are applicable to this transformation, which gives aryl or alkenyl nitriles, respectively.

PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS KINASE JAK-2 INHIBITORS

A compound of the general formula (I), useful for treating myeloproliferative, cancer,or inflammatory diseases, wherein Q represents a six-membered heteroaromatic ring containing 2 N atoms and R1 is hydrogen atom,or Q represents a five-membered heteroaromatic ring containing 1 or 2 heteroatoms selected from the group consisting of N and S,one substituent R1 is attached at C or N atom of said Q ringand R1 is selected from the group consisting of C1-C4-alkyl and C3-C4-cycloalkyl;R2 represents-NR7aR7bor-CH2-NR8aR8b;R3 represents C1-C4-alkyl;R4 represents phenylora 5-or 6-membered heteroarylcontaining 1 or 2 heteroatoms selected from the group consisting of N and S, and R4 is unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of halogen, trifluoromethyl,hydroxyl and C1-C4-alkoxyl;R5 and R6 independently represent hydrogenatom or C1-C4-alkyl,and at least one of R5 and R6 represents hydrogen atom;and other substituents are as defined in the specification; and pharmaceutically acceptable salts thereof.

Bronsted acid mediated nitrogenation of propargylic alcohols: An efficient approach to alkenyl nitriles

A novel and efficient approach to alkenyl nitriles from readily available propargylic alcohols has been developed. This nitrogenation reaction is transition-metal-free and could be conducted under air at ambient temperature, which makes this protocol promising and practical. Moreover, NH4Br is disclosed as an efficient additive to promote the stereoselectivity of this reaction. the Partner Organisations 2014.