144478-67-1

Basic information

• Product Name: 2-[[2-(hydroxymethyl)cyclohexyl]amino]acetonitrile
• Synonyms: {[2-(Hydroxymethyl)cyclohexyl]amino}acetonitrile; acetonitrile, 2-[[2-(hydroxymethyl)cyclohexyl]amino]-
• CAS NO: 144478-67-1
• Molecular Formula: C₉H₁₆N₂O
• Molecular Weight: 168.24
• Mol File: 144478-67-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 347.6°C at 760 mmHg
• Flash Point: 164°C
• Density: 1.05g/cm³
• Vapor Pressure: 3.27E-06mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: 2-[[2-(hydroxymethyl)cyclohexyl]amino]acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[[2-(hydroxymethyl)cyclohexyl]amino]acetonitrile(144478-67-1)
• EPA Substance Registry System: 2-[[2-(hydroxymethyl)cyclohexyl]amino]acetonitrile(144478-67-1)

Safety Data

• Hazardous Substances Data: 144478-67-1(Hazardous Substances Data)

Upstream product

• 213993-31-8 (1S,2S)-2-amino-cyclohexylmethanol 
• 144540-72-7 trans-hexahydrophthalide 
• 116174-39-1 ((1S,2S)-2-Hydroxymethyl-cyclohexyl)-pyrrolidin-1-yl-methanone 
• 116174-40-4 (1S,2S)-2-Hydroxymethyl-cyclohexanecarboxylic acid amide 
• 88335-91-5 cyclohexane-1,2-dicarboxylic acid monomethyl ester 
• 4336-20-3 dimethyl 1,2-cyclohexanedicarboxylate 
• 65376-02-5 (1S,6R)-8-oxabicyclo[4.3.0]nonan-7-one 
• 151-50-8 potassium cyanide 
• 84909-70-6 (4aS,8aS)-Octahydro-benzo[d][1,3]oxazine 

Downstream Products

• 144478-68-2 (2R,3aR,7aS)-1-Benzoyl-octahydro-indole-2-carbonitrile 
• 144478-69-3 (2S,3aR,7aS)-1-Benzoyl-octahydro-indole-2-carbonitrile 
• 144540-73-8 Methanesulfonic acid (1S,2S)-2-(benzoyl-cyanomethyl-amino)-cyclohexylmethyl ester 
• 1158650-42-0 N-Cyanomethyl-N-((1S,2S)-2-hydroxymethyl-cyclohexyl)-benzamide 

Relevant articles and documents

Stereoselective synthesis of a trans-octahydroindole derivative, precursor of trandolapril (RU 44 570), an inhibitor of angiotensin converting enzyme

We describe a stereoselective synthesis of the trans-octahydroindole-2-carboxylic acid 2 a key intermediate in the elaboration of Trandolapril (RU 44 570) 1. The optically active starting material used was obtained by an enzymatic hydrolysis.