116174-39-1

Upstream product

• 123-75-1 pyrrolidine 
• 65376-02-5 (1S,6R)-8-oxabicyclo[4.3.0]nonan-7-one 
• 88335-91-5 cyclohexane-1,2-dicarboxylic acid monomethyl ester 
• 4336-20-3 dimethyl 1,2-cyclohexanedicarboxylate 

Downstream Products

• 213993-31-8 (1S,2S)-2-amino-cyclohexylmethanol 
• 144478-67-1 ((1S,2S)-2-Hydroxymethyl-cyclohexylamino)-acetonitrile 
• 116174-40-4 (1S,2S)-2-Hydroxymethyl-cyclohexanecarboxylic acid amide 
• 144478-68-2 (2R,3aR,7aS)-1-Benzoyl-octahydro-indole-2-carbonitrile 
• 144478-69-3 (2S,3aR,7aS)-1-Benzoyl-octahydro-indole-2-carbonitrile 
• 144540-73-8 Methanesulfonic acid (1S,2S)-2-(benzoyl-cyanomethyl-amino)-cyclohexylmethyl ester 
• 1158650-42-0 N-Cyanomethyl-N-((1S,2S)-2-hydroxymethyl-cyclohexyl)-benzamide 

Relevant academic research and scientific papers

Stereoselective synthesis of a trans-octahydroindole derivative, precursor of trandolapril (RU 44 570), an inhibitor of angiotensin converting enzyme

We describe a stereoselective synthesis of the trans-octahydroindole-2-carboxylic acid 2 a key intermediate in the elaboration of Trandolapril (RU 44 570) 1. The optically active starting material used was obtained by an enzymatic hydrolysis.