144486-11-3Relevant academic research and scientific papers
Palladium-catalyzed anti-Markovnikov oxidative acetalization of activated olefins with iron(iii) sulphate as the reoxidant
Fernandes, Rodney A.,Kumar, Praveen,Yadav, Sandhya S.
, p. 427 - 443 (2022/01/20)
This paper discloses the efficient palladium-catalyzed anti-Markovnikov oxidative acetalization of activated terminal olefins with iron(iii) sulfate as the reoxidant. This methodology requires mild reaction conditions and shows high regioselectivity toward anti-Markovnikov products and compatibility with a wide range of functional groups. Iron(iii) sulphate was the sole reoxidant used in this method. Various olefins like vinylarenes, aryl-allylethers, aryl or benzyl acrylates and homoallylic alcohols all reacted well providing anti-Markovnikov acetals, some of which represent orthogonally functionalized 1,3- and 1,4-dioxygenated compounds.
BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF
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Page/Page column 110; 111, (2019/02/02)
The invention provides novel compounds having the general formula (I): (I) wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
BICYCLIC SULFONES AND SULFOXIDES AND METHODS OF USE THEREOF
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Paragraph 0390-0391, (2019/05/15)
The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of usi
Stereoselective Barbier-Type Allylations and Propargylations Mediated by CpTiCl3
López-Martínez, Josefa L.,Torres-García, Irene,Rodríguez-García, Ignacio,Mu?oz-Dorado, Manuel,álvarez-Corral, Miriam
, p. 806 - 816 (2019/01/24)
CpTiCl2, prepared in situ by manganese reduction of CpTiCl3, is an excellent new system for the Barbier-type allylation and propargylation of carbonyl compounds. It can be used in catalytic amounts when combined with Et3N·HBr/TMSBr, which acts as a regenerating system. The high regio- and stereoselectivity shown by this system makes it useful for prenylation and crotylation processes in the synthesis of natural products.
Copper-Promoted 6- endo-trig Cyclization of β,γ-Unsaturated Hydrazones for the Synthesis of 1,6-Dihydropyridazines
Guo, Yong-Qiang,Zhao, Mi-Na,Ren, Zhi-Hui,Guan, Zheng-Hui
supporting information, p. 3337 - 3340 (2018/06/11)
A novel and efficient strategy for the synthesis of 1,6-dihydropyridazines via copper-promoted 6-endo-trig cyclization of readily available β,γ-unsaturated hydrazones have been developed. A series of 1,6-dihydropyridazines have been synthesized by this method with good yields, high functional group tolerance, and remarkable regioselectivity under mild conditions. Importantly, the 1,6-dihydropyridazines can be efficiently converted to biologically important pyridazines in the presence of NaOH.
A ionic the bistriphenyl make PVC possess enough preparation and application of (V) complex
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Paragraph 0056; 0057, (2017/01/02)
The invention provides a preparation method of an ionic type bis-triphenyl organic antimony (V) complex and a method for synthesizing allyl alcohol compounds under catalysis of the ionic type bis-triphenyl organic antimony (V) complex. The complex is a cationic type organic antimony complex, wherein two antimony atoms in the complex are bridged by virtue of oxygen atoms and are pentavalent; and each antimony atom is in coordination with one water molecule, and an ionic bond is formed by the entire organic antimony cationic part with corresponding anions. The synthetic method comprises the following step: by taking the bis-triphenyl organic antimony (V) complex as a catalyst, taking a commonly-used organic solvent as a reaction solvent, and taking aldehyde and tetraallyltin as raw materials, performing reaction. The synthetic method can be used for providing a novel low-cost and 'green' route for preparing the allyl alcohol compounds, and has the advantages that target product selectivity and yield are high, the catalyst can be repeatedly used, corresponding ketone can be obtained by performing simple column chromatography separation on the product, and the whole reaction and separation process is simple to operate and is green and environment-friendly.
A Mild, efficient protocol for the synthesis of homoallylic alcohols using potassium allyltrifluoroborate promoted by salicylic acid
Silva, Jadson F.,Lima, Josefa A.C.,De Freitas, Jucleiton J.R.,Freitas, Ladjane P.S.R.,Menezes, Paulo H.,Freitas, Juliano C.R.
, p. 49 - 57 (2015/12/31)
Background: In the current decade, organotrifluoroborates have attained remarkable development in Chemistry and Materials. This can be evidenced by the increasing number of articles, review articles and patents devoted to this subject. As a consequence, the number of citations derived from papers dealing with this subject has experienced an exponential growth in the last years. The aim of this paper to describe a methodology based on the use of potassium allyltrifluoroborate for the synthesis of homoallylic alcohols using water as a co-solvent and under mild reaction conditions. Methods: The methodology is very robust (wide range of aldehydes) and simple, it uses low catalyst loadings and it is synthetically useful because it could be applied for the synthesis of more complex compounds. In addition, detailed experimental procedures, including the preparation of the starting materials, as well as the corresponding 1H, 13C, 19F and 11B spectra for all synthesized compounds are provided. Results: The method is environmentally friendly while it uses water as a solvent and the desired compounds containing different functionalities were obtained in moderate to good yields (60-93%) without the need of further purification in a very chemo- and regioselective way. Conclusion: Salicylic acid can efficiently promote the allylation of aldehydes using potassium allyltrifluoroborate at room temperature to yield the corresponding homoallylic alcohols in moderate to good yields. The method is efficient and environmentally friendly while it uses water as co-solvent. In addition the method is regio- and chemoselective and could be applied in the synthesis of more complex homoallylic alcohols.
Ter-pyridine catalyzed allylation of aldehydes and ketones under metal-free condition
Datilus, Vicklyn,Abdulkarim, Mary,Patrizio, Andrew,Kaur, Parminder
supporting information, p. 2778 - 2781 (2016/06/09)
Ter-pyridine derivatives were found to be potential catalyst for homoallylation of carbonyl groups. High yields of the products with short reaction times of ～2 h were observed in several cases. These new catalysts work efficiently with the simple reagent such as allyl magnesium bromide and hence can avoid the use of other sensitive or toxic reagents. It was found that the presence of polar groups on the catalysts made them extremely efficient without the presence of any metal salts.
Strong Lewis acids of air-stable binuclear triphenylantimony(V) complexes and their catalytic application in C-C bond-forming reactions
Li, Ningbo,Qiu, Renhua,Zhang, Xiaohong,Chen, Yun,Yin, Shuang-Feng,Xu, Xinhua
, p. 4275 - 4281 (2015/06/08)
Two air-stable novel Lewis acids of triphenylantimony(V) pentafluorbezenesulfonates (2) and perfluorooctanesulfonates (3) were successfully synthesized and characterized. X-ray studies and thermo-gravimetric analysis found that these complexes showed high anti-hydrolyzability and thermal stability. The high catalytic activity and excellent recyclability of these complexes were achieved in the Michael addition reaction and the allylation reaction. On account of their stability, storability, as well as catalytic efficiency, these complexes should find a broad range of utility in organic synthesis.
CuI catalyzed Barbier type allylation of aldehyde in presence of S1,S2-dipyridin-2-yl ferrocene-1,1′-dicarbothioate as ligand
Kashyap, Bishwapran,Phukan, Prodeep
, p. 662 - 670 (2015/05/27)
Ferrocene based ligand S1 ,S2-dipyridin-2-yl ferrocene-1,1′-dicarbothioate has been prepared from 1,1′-ferrocene-dicarboxylic acid. The ligand has been used successfully in the SnCl2.2H2O mediated Barbier type a
