1445-23-4Relevant articles and documents
Method for preparing 2-hydroxy-4-methyltetrahydropyran
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Paragraph 0059; 0061; 0062, (2017/07/21)
The invention relates to a method for preparing 2-hydroxy-4-methyltetrahydropyran (MHP) from using 3-methyl-3-buten-1-ol (IPEA) as a raw material under the catalysis of a rhodium compound and a tertiary phosphine ligand. After a reaction is finished, water extraction is performed for separating products from catalysts, wherein the rhodium catalyst and the tertiary phosphine ligand are reserved in an organic phase, the products are reserved in an aqueous phase, the conversion rate of IPEA can be as high as 99.7%, and the MHP selectivity of the products can be up tp 85.9%. The method solves the difficult problem that the costly rhodium catalyst is difficult to recover in a hydroformylation reaction process, and is favorable for industrial application.
Asymmetric ring-closing metathesis reactions
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Page 9-10, (2010/02/07)
A composition and method for the catalytic conversion of a racemic mixture of dienes to a cyclic olefin by a ring-closing metathesis (RCM) reaction are disclosed. The composition, a transition metal complex with an M=C reaction site, contains a bidentate dialkoxide of at least 80% optical purity. Because the M=C reaction site is of a sufficient shape specificity, conferred in part by the dialkoxide of sufficient rigidity and an M=N-R1 site, reacting the composition with a mixture of two enantiomeric dienes results in an olefin metathesis product that has at least a 50% enantiomeric excess of one enantiomer in the mixture. A method is also provided for reacting a composition with a racemic diene mixture to generate a metathesis product that has an enantiomeric excess of at least 50%.
Titanium Tetrachloride Induced Fries Rearrangement: A New Route to Disubstituted 2'-Hydroxypropiophenones
Martin, Robert,Demerseman, Pierre
, p. 25 - 28 (2007/10/02)
Fries rearrangement of some dialkylphenyl propionates with titanium tetrachloride proves to be a convenient route to hindered dialkyl 2'-hydroxypropiophenones.The sequential use of soft titanium tetrachloride to perform the Fries rearrangement followed by hard aluminum chloride to achieve the elimination of a protecting tert-butyl group allows the synthesis of some previously unknown 3',6'- and 5',6'-dialkyl-2-hydroxypropiophenones.