144540-75-0

Usage

Uses

Used in Pharmaceutical Research and Development:
(2S,3aR,7aS)-1H-Octahydroindole-2-carboxylic acid hydrochloride is used as a building block for the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients. Its unique structure and properties make it a versatile compound in the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry:
(2S,3aR,7aS)-1H-Octahydroindole-2-carboxylic acid hydrochloride is used as a valuable compound in the field of medicinal chemistry due to its potential biological activities and therapeutic applications. Researchers can explore its interactions with various biological targets and pathways, leading to the discovery of new treatments for various diseases and conditions.
Used in Drug Synthesis:
(2S,3aR,7aS)-1H-Octahydroindole-2-carboxylic acid hydrochloride is used as a key component in the synthesis of various drugs. Its unique chemical properties allow it to be incorporated into the molecular structures of different pharmaceuticals, potentially enhancing their efficacy and safety.
Used in Drug Design:
(2S,3aR,7aS)-1H-Octahydroindole-2-carboxylic acid hydrochloride is used as a starting point for drug design. Its structural features can be modified and optimized to create new drug candidates with improved pharmacological properties, such as increased potency, selectivity, and reduced side effects.
Used in Drug Delivery Systems:
(2S,3aR,7aS)-1H-Octahydroindole-2-carboxylic acid hydrochloride can be used in the development of drug delivery systems to improve the bioavailability and therapeutic outcomes of various pharmaceuticals. Its chemical properties can be exploited to enhance the solubility, stability, and targeted delivery of drugs to specific tissues or cells.

InChI:InChI=1/C9H15NO2.ClH/c11-9(12)8-5-6-3-1-2-4-7(6)10-8;/h6-8,10H,1-5H2,(H,11,12);1H/t6-,7+,8+;/m1./s1

Upstream product

• 1346773-51-0 (1S,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride 
• 1346773-51-0 (1R,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate hydrochloride 
• 1260890-70-7 (2S,3aR,7aS)-ethyl octahydro-1H-indole-2-carboxylate hydrochloride 
• 191986-93-3 (1R,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate 
• 191986-95-5 (1S,2S)-ethyl 2-((S)-1-phenylethylamino)cyclohexanecarboxylate 
• 1260890-99-0 (2S,3aR,7aS)-ethyl octahydro-1H-indole-2-carboxylate 
• 1260890-69-4 (2S,3aR,7aS)-ethyl 1-((S)-1-phenylethyl)octahydro-1H-indole-2-carboxylate 
• 1260890-68-3 ethyl 2-(((1S,2S)-2-((methylsulfonyloxy)methyl)cyclohexyl)((S)-1-phenylethyl)amino)acetate 
• 1260890-64-9 ethyl 2-(((1S,2S)-2-(hydroxymethyl)cyclohexyl)((S)-1-phenylethyl)amino)acetate 
• 1260890-62-7 (1S,2S)-2-[(S)-1-phenylethylamino]cyclohexylmethanol 
• 53898-03-6 2-(S-1-phenylethylamino)-cyclohex-1-enecarboxylic acid ethyl ester 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 

Downstream Products

• 145641-35-6 phenylmethyl-(2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride 

Relevant academic research and scientific papers

PROCESSES FOR THE SYNTHESIS OF (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE CARBOXYLIC ACID AS AN INTERMEDIATE FOR TRANDOLAPRIL

Processes for the preparation of (2S, 3aR, 7aS) -octahydro-1H-indole-20carboxylic acid hydrochloride starting from (1S, 2S) -2- [ (S) -1- phenylethyl amino] cyclohexyl) methanol are described.

Process for the preparation of perindopril and salts thereof

The present invention describes a novel method for the synthesis of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid, or of one of its aryl esters of formula XIII wherein X and Y are a hydrogen atom, a halogen, alkyl, alkoxyl or nitro group, and the conversion of the paranitrobenzyl ester of formula X into Perindopril of formula I or one of its salts.