144564-22-7Relevant academic research and scientific papers
MODULATORS OF REV-ERB
-
, (2015/07/16)
The subject matter herein concerns the identification and development of potent synthetic REV-ERB ligands, such as in vivo agonists and antagonists. These compounds allow for characterization of the effects of modulation of this receptor in vivo specifically on circadian behavior and metabolism, and have suitable characteristics for development of medicinal compounds useful for treatment of malconditions such as diabetes, obesity, atherosclerosis, dyslipidemia, a circadian rhythm disorder, coronary artery disease, bipolar disorder, depression, cancer, a sleep disorder, an anxiety disorder, an addiction disorder, a bone-related disorder such osteoporosis, a skeletal muscle disease, e.g., with compromised exercise capacity, or an autoimmune disorder such as psoriasis, multiple sclerosis, inflammatory bowel disease, and others.
Synthesis of chiral catalysts for the enantioselective addition of diethylzinc to aromatic aldehydes
Stingl,Martens
, p. 2745 - 2756 (2007/10/02)
The reaction of diethylzinc with aromatic aldehydes and (S)-porretine derived catalysts was investigated. The synthesis of new chiral catalysts is also described.
