144584-15-6Relevant academic research and scientific papers
Palladium(0)-catalysed regioselective cyclisations of 2-amino(tosyl) benzamides/sulphonamides: The stereoselective synthesis of 3-ylidene-[1,4]benzodiazepin-5-ones/benzo[f][1,2,5]thiadiazepine-1,1-dioxides
Mondal, Debasmita,Pal, Gargi,Chowdhury, Chinmay
, p. 5462 - 5465 (2021/06/09)
The Pd(0) catalysed cyclisation reactions betweentert-butyl propargyl carbonates and 2-aminotosyl benzamides or sulphonamides deliver 1,4-benzodiazepin-5-ones or sultam derivatives, key components of many biologically active compounds. But 2-amino benzamides/sulphonamides require propargyl carbonates substituted at acetylenic carbon to undergo the reaction resulting in the stereoselective formation of the said products.
Use of pentafluorophenyl esters for one-pot protection/activation of amino and thiol carboxylic acids
Gayo, Leah M.,Suto, Mark J.
, p. 4915 - 4918 (2007/10/03)
As part of our efforts in the area of combinatorial chemistry, we have been exploring new methods for the construction of combinatorial libraries in a bidirectional fashion. Herein, we describe a new one-pot procedure for the simultaneous protection/activation of amino and thiol carboxylic acids using pentafluorophenyl trifluoroacetate (TFAPfp) and related pentafluorophenyl reagents (FmocPfp and AcPfp).
Etude du comportement de benzoxazinones, substituees en position 2 par des groupements (per)halogenes, vis-a-vis de l'aniline
Boutevin, B.,Rasoloarijao, L. Ranjalahy,Rouseau, A.,Garapon, J.,Sillion, B.
, p. 29 - 41 (2007/10/02)
This study describes firstly the synthesis of benzoxazinones substituted in position 2 by halogenated groups such as -(CH2)n-RF,Cl where n=0, 1 and 2 and RF,Cl is a perhalogenated group, and secondly the reaction of these new benzoxazinones with aniline in different media.Thus it is shown that the behaviour of trifluoromethyl-2-benzoxazinone towards aniline is different, in most cases, in comparison with benzoxazinones substituted by perfluorinated groups CnF2n+1 with n=2, 3 and 7.Under certain conditions (hot ethanol and aniline with triphenyl phosphite), it is observed that nucleophilic attack of aniline only occurs on the carbonyl group when benzoxazinones are substituted by an electron-withdrawing group such as C2F5, C3F7 and C7F15.
