1445890-99-2

Upstream product

• 1445890-97-0 ethyl 4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrole-3-carboxylate 
• 1188163-01-0 ethyl 4-(2-chlorophenyl)-1H-pyrrole-3-carboxylate 
• 24393-51-9 (E)-ethyl 2-chlorocinnamate 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 1445891-01-9 4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrole-3-carbaldehyde 
• 1445891-02-0 4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine 
• 1445891-03-1 4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine 
• 1445891-05-3 4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-N-(2,4-dimethoxybenzyl)-5-methylpyridin-2-amine 
• 1445891-06-4 N-{4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-N-(2,4-dimethoxybenzyl)cyclopropanecarboxamide 
• 1445889-73-5 N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}cyclopropanecarboxamide 

Relevant academic research and scientific papers

HETEROARYLS AND USES THEREOF

This invention provides compounds of formula IB: and also provides compounds of formulas ID, IIB, VB, and IIC: wherein HY, R1, R2, G5, G6, G7, G8, and G9 are as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.