14459-29-1 Usage
Uses
Different sources of media describe the Uses of 14459-29-1 differently. You can refer to the following data:
1. antidepressant, antineoplastic
2. Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (coverted to alcohols). It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy. Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.
Definition
ChEBI: A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.
Hazard
Toxic. Reported to be preferentially
absorbed by cancerous tissues, making them fluoresce under UV light.
Purification Methods
Purify it by dissolving it in EtOH Hematoporphyrin and adding H2O or Et2O to give deep red crystals. It has also been recrystallised from MeOH. UV has max at 615.5, 565, 534.4 and 499.5nm in 0.1N NaOH, and 597, 619, 634, 653, 683 and 701nm in 2N HCl [Falk Porphyrins and Metalloporphyrins Elsevier, NY, p 175 1964, LCCCNo 63-19821.] It is used in the affinity chromatographic purification of Heme proteins [Olsen Methods Enzymol 123 324 1986]. The O-methyl-dimethyl ester has m 203-206o (from CHCl3/MeOH), and the O,O'-dimethyl-dimethyl ester has m 145o (from CHCl3/MeOH). [Paul Acta Chem Scand 5 389 1951, Beilstein 26 III/IV 3157, and 3158 for the HCl.]
Check Digit Verification of cas no
The CAS Registry Mumber 14459-29-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,4,5 and 9 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 14459-29:
(7*1)+(6*4)+(5*4)+(4*5)+(3*9)+(2*2)+(1*9)=111
111 % 10 = 1
So 14459-29-1 is a valid CAS Registry Number.
InChI:InChI=1/C34H38N4O6/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27/h11-14,19-20,35,38-40H,7-10H2,1-6H3,(H,41,42)(H,43,44)/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13-
14459-29-1Relevant articles and documents
Interaction of dicarboxylic metalloporphyrins with liposomes. The effect of pH on membrane binding revisited
Kepczynski, Mariusz,Ehrenberg, Benjamin
, p. 486 - 492 (2002)
The acid-base properties of Zn-hematoporphyrin IX (ZnHP) and Zn-mesoporphyrin IX (ZnMP) and the effect of pH on their binding to liposomes have been studied. The ionization constants for the two carboxylate groups of ZnHP were calculated by principal comp
Antibody-therapeutic agent conjugates
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, (2008/06/13)
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