75162-60-6 Usage
General Description
2,4-diacetylhematoporphyrin dimethyl ester, also known as DHE, is a chemical compound that is used in photodynamic therapy for the treatment of various cancers and non-malignant conditions. It is a derivative of hematoporphyrin, a natural compound found in the human body, and is used to target and destroy cancerous cells when activated by light. DHE is administered to patients intravenously and accumulates in the tumor tissue, making the cancer cells sensitive to light. When the tumor is exposed to a specific wavelength of light, the DHE becomes activated and produces toxic substances that kill the cancer cells. This treatment method has shown promising results in the treatment of skin, lung, and bladder cancers, as well as certain non-malignant conditions such as age-related macular degeneration. However, DHE can cause side effects such as skin sensitivity to light and should be used under the supervision of a medical professional.
Check Digit Verification of cas no
The CAS Registry Mumber 75162-60-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,1,6 and 2 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 75162-60:
(7*7)+(6*5)+(5*1)+(4*6)+(3*2)+(2*6)+(1*0)=126
126 % 10 = 6
So 75162-60-6 is a valid CAS Registry Number.
75162-60-6Relevant articles and documents
The Chemistry of Pyrrolic Compounds. XLV. Haematoporphyrin Derivative: Haematoporphyrin Diacetate as the Main Product of the Reaction of Haematoporphyrin with a Mixture of Acetic and Sulfuric Acids
Clezy, Peter S.,Hai, Ton That,Henderson, Robert W.,Thuc, Le van
, p. 585 - 597 (2007/10/02)
A mixture of acetic and sulfuric acids converts haematoporphyrin into a complex mixture of porphyrins of which the main product has been characterized as the diacetate (1g).Other compounds identified in the reaction mixture were the known vinylporphyrins (1b-d), (1h) and (1i) and the isomeric monoacetoxyethyl(monohydroxyethyl)porphyrins (1l) and (1m).Analysis of the reaction mixture was complicated by the presence of 1'-ethoxyethyl derivatives (1e) or (1f), (1j) and (1k) which presumably arose by solvolysis of the corresponding acetate with ethanol present in the chloroform used for the the chromatographic separation.
