1446103-03-2Relevant academic research and scientific papers
Catalytic Friedel-Crafts reaction of aminocyclopropanes
De Nanteuil, Florian,Loup, Joachim,Waser, Jeroime
supporting information, p. 3738 - 3741 (2013/08/15)
A Lewis acid catalyzed Friedel-Crafts reaction between donor-acceptor aminocyclopropanes and indoles and other electron-rich aromatic compounds is reported. Indole alkylation at the C3 position was generally obtained for a broad range of functional groups and substitution patterns. In the case of C3-substituted indoles, C2 alkylation was observed. The reaction gives a rapid access to gamma amino acid derivatives present in numerous bioactive molecules.
