3485-84-5

Basic information

• Product Name: N-VINYLPHTHALIMIDE
• Synonyms: 2-Ethenyl-1H-isoindole-1,3(2H)-dione;2-ethenyl-1h-isoindole-3(2h)-dione;2-Vinyl-1H-isoindole-1,3(2H)-dione;Phthalimide, N-vinyl-;N-VINYLPHTHALIMIDE;N-Vinylphthalimide,99%;2-Ethenylisoindoline-1,3-dione;2-Vinyl-2H-isoindole-1,3-dione
• CAS NO: 3485-84-5
• Molecular Formula: C₁₀H₇NO₂
• Molecular Weight: 173.17
• EINECS: 222-473-4
• Product Categories: N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides;Fused Ring Systems;High Refractive Index MonomersPolymer Science;Monomers;Photonic and Optical Materials;Vinyl Halides, Amines, Amides, and Other Vinyl Monomers;Waveguide Materials
• Mol File: 3485-84-5.mol
• Article Data: 33

Chemical Properties

• Melting Point: 84-86 °C(lit.)
• Boiling Point: 151 °C / 9mmHg
• Flash Point: 140.5 °C
• Appearance: Off-white to light yellow/Crystalline Powder
• Density: 1.402
• Vapor Pressure: 0.000866mmHg at 25°C
• Refractive Index: 1.713
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -2.45±0.20(Predicted)
• BRN: 127880
• CAS DataBase Reference: N-VINYLPHTHALIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-VINYLPHTHALIMIDE(3485-84-5)
• EPA Substance Registry System: N-VINYLPHTHALIMIDE(3485-84-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 3485-84-5(Hazardous Substances Data)

Usage

Chemical Properties

off-white to light yellow crystalline powder

Uses

N-Vinylphthalimide is a reactant that has been used in the preparation of trifluoromethylaryl-substituted fused piperidinecarboxamides as TRPM8 cation channel inhibitors.

InChI:InChI=1/C10H7NO2/c1-2-11-9(12)7-5-3-4-6-8(7)10(11)13/h2-6H,1H2

Upstream product

• 53701-47-6 2-(1,3-dioxoisoindolin-2-yl)propanoyl chloride 
• 22156-21-4 rac-1-(1,3-dioxoisoindolin-2-yl)ethyl acetate 
• 5466-90-0 2-(1,3(2H)-dioxo-1H-isoindol-2-yl)ethyl acetate 
• 136918-14-4 phthalimide 
• 74-86-2 acetylene 
• 574-98-1 2-(2-bromoethyl)isoindoline-1,3-dione 
• 95445-79-7 3-methyl 5-(1-methylethyl) 4-(3-chloro-6-fluoro-2-(trifluoromethyl)phenyl)-2-(fluoromethyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate 
• 5587-42-8 imidazolyl sodium 
• 1085337-04-7 2-vinyl-1H-benzo[f]isoindole-1,3(2H)-dione 
• 2065-67-0 tetraphenylphosphonium iodide 
• 121-45-9 phosphorous acid trimethyl ester 
• 883-44-3 N-(3-hydroxypropyl)phthalimide 
• 1246973-75-0 2-ethynylisoindoline-1,3-dione 
• 89-51-0 Homophthalic acid 

Downstream Products

• 1018683-94-7 2-[(2R,3aR,7R)-4-oxo-7-phenylhexahydroisoxazolo[3,2-c][1,4]oxazin-2-yl]isoindoline-1,3-dione 
• 2436-29-5 3-(N-phthaloyl)propionaldehyde 
• 5022-29-7 N-ethylphthalimide 
• 1243579-27-2 S-[1-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-4-(4-fluorophenyl)-4-oxo-butyl]-O-ethyl dithiocarbonate 
• 1243579-30-7 S-[4-(4-bromo-phenyl)-1-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-4-oxo-butyl]-O-ethyl dithiocarbonate 
• 1243579-38-5 S-{1-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[4-oxo-1-(toluene-4-sulfonyl)-piperidin-3-yl]-ethyl}-O-ethyl dithiocarbonate 
• 1243579-32-9 S-[4-(5-bromo-2-methoxy-phenyl)-1-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-4-oxo-butyl]-O-ethyl dithiocarbonate 
• 1000511-34-1 2-(4-acetylphenethyl)isoindoline-1,3-dione 
• 73365-03-4 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal 
• 1114884-11-5 2-((1S,2R)-2-(4-chlorophenyl)-2-(4,4-dimethylpent-2-ynoyl)cyclopropyl)isoindoline-1,2-dione 

Relevant articles and documents

Synthesis and biological properties of novel structural analogs of isothiobarbamine

Novel structural analogs of isothiobarbamine, which differ from the prototype scaffold by the substituent at position 2 of the pyrimidine heterocycle, were for the first time synthesized and characterized. Data acquired in pharmacological experiments in vivo revealed that compounds 1b—d and 10 increase physical productivity, whereas compounds 1c and 10 exhibit a nootropic effect, compound 8a shows a psychostimulating effect, and compound 1b exhibits anxiolytic properties. The results reported herein indicate that the drug discovery based on new structural analogs of isothiobarbamine is promising since it may lead to drugs for the prevention and treatment of asthenia (chronic fatigue syndrome).

Normal Alpha Olefin Synthesis Using Dehydroformylation or Dehydroxymethylation

The present invention discloses processes for producing normal alpha olefins, such as 1-hexene, 1-octene, 1-decene, and 1-dodecene in a multistep synthesis scheme from another normal alpha olefin. Also disclosed are reactions for converting aldehydes, primary alcohols, and terminal vicinal diols into normal alpha olefins.

Michaelis-Arbuzov-type reaction of 1-imidoalkyltriarylphosphonium salts with selected phosphorus nucleophiles

In this study, Michaelis-Arbuzov-type reaction of 1-imidoalkyltriarylphosphonium salts with phosphites, phosphonites, and phosphinites was used in the synthesis of a wide range of phosphorus analogs of α-amino acids such as 1-imidoalkylphosphonates, 1-imidoalkylphosphinates, and 1-imidoalkylphosphine oxides. Large differences were observed in the reactivity of substrates depending on their structure, especially on the type of phosphonium moiety and N-protecting group. The conditions under which the expected products can be obtained in good to excellent yields have been developed. Mechanistic aspects of the transformation have been provided.