1446175-09-2Relevant articles and documents
Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines
Temburnikar, Kartik W.,Ross, Christina R.,Wilson, Gerald M.,Balzarini, Jan,Cawrse, Brian M.,Seley-Radtke, Katherine L.
, p. 4354 - 4363 (2015)
In vitro evaluation of the halogenated pyrrolo[3,2-d]pyrimidines identified antiproliferative activities in compounds 1 and 2 against four different cancer cell lines. Upon screening of a series of pyrrolo[3,2-d]pyrimidines, the 2,4-Cl compound 1 was foun
Synthesis of 2′-deoxy-9-deaza nucleosides using heck methodology
Temburnikar, Kartik,Brace, Kelin,Seley-Radtke, Katherine L.
, p. 7305 - 7311 (2013/08/23)
During the synthesis of a series of 2′-deoxy-9-deaza nucleosides using Heck methodology, the necessity for a pyrrole protecting group was discovered. The results of this brief study revealed that the benzyloxymethyl (BOM) group proved optimal, and Heck coupling using Jeffery conditions increased the coupling yield significantly. The results are reported herein.