30958-38-4

Upstream product

• 13162-26-0 2,4-dichloro-6-methyl-5-nitropyrimidine 
• 20194-18-7 sodium phenyl-methanolate 
• 16632-21-6 5-nitro-6-methyluracil 

Downstream Products

• 222631-55-2 2,4-bis-O-benzyl-5-nitro-6-β-dimethylaminovinylpyrimidine 
• 1446175-04-7 7-iodo-2,4-bis-benzyloxy-5H-pyrrolo[3,2-d]-pyrimidine 
• 1446175-09-2 2,4-bis-benzyloxy-5-N-boc-7-iodopyrrolo[3,2-d]pyrimidine 
• 222631-58-5 (1S)-1-(2,6-di-O-benzyl-7-N-tert-butyldimethylsilyl-9-deazaxanthin-9-yl)-5-O-tert-butyldimethylsilyl-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-D-ribitol 
• 222631-54-1 (1S)-1-(9-deazaxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol hydrochloride 
• 299916-75-9 (1S)-1-(7-N-tert-butyldimethylsilyl-9-deazaxanthin-9-yl)-5-O-tert-butyldimethylsilyl-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-D-ribitol 
• 364046-06-0 7-N-benzyl-2,6-di-O-benzyl-9-bromo-9-deazaxanthine 
• 222631-57-4 2,6-di-O-benzyl-9-bromo-7-N-tertbutyldimethylsilyl-9-deazaxanthine 
• 222631-56-3 2,4-bis-benzyloxy-5H-pyrrolo[3,2-d]pyrimidine 

Relevant academic research and scientific papers

Process for preparing 2-pyrrolidinyl-1H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside metabolism

A process of preparing a compound of the formula (I) wherein B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and Z is selected from OH, hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted all, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof, which comprises reacting a compound of the formula (II) ?with an anion produced by abstraction of the bromine or iodine atom from a compound of formula (XIX), ?to form a compound of formula (XX) The compound of formula (XX) is N- and O-deprotected to obtain the compound of formula (I).

Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: Convergent synthesis of the aza-C-nucleoside immucillins

Means have been developed for the synthesis and addition of 9-deaza-9-lithiopurine derivatives to the carbohydrate-derived cyclic imine 6 in facile convergent syntheses of biologically active aza-C-nucleosides.