1446254-71-2Relevant academic research and scientific papers
A novel allylic substitution strategy to four-component synthesis of pyrazole-substituted fused pyrroles
Tu, Xing-Chao,Fan, Wei,Jiang, Bo,Wang, Shu-Liang,Tu, Shu-Jiang
supporting information, p. 6100 - 6107 (2013/07/27)
The selective formation of pyrazole-substituted fused pyrroles through HOAc-mediated multicomponent reactions of enaminones with arylglyoxal monohydrates and generated in situ pyrazole-3-carboxylates was developed. It constructed a variety of bis-heterocyclic pairs under mild conditions in a domino process. Reaction driving tandem cyclization/allylic esterification/ allylic substitution was achieved through the formation of in situ generation of allyl esters and pyrazole-3-carboxylates from readily available starting materials. Up to two new five-membered heterocyclic rings and five new sigma bonds including a C(sp3)-C(sp2) bond were formed in a single reaction without isolated intermediates.
