144629-55-0

Basic information

• Product Name: 2'-EE-10-Deacetyl-7,10-bis(trichloroethoxycarbonyl)-taxol
• CAS NO: 144629-55-0
• Molecular Weight: 1234.79
• Mol File: 144629-55-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-EE-10-Deacetyl-7,10-bis(trichloroethoxycarbonyl)-taxol(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-EE-10-Deacetyl-7,10-bis(trichloroethoxycarbonyl)-taxol(144629-55-0)
• EPA Substance Registry System: 2'-EE-10-Deacetyl-7,10-bis(trichloroethoxycarbonyl)-taxol(144629-55-0)

Safety Data

• Hazardous Substances Data: 144629-55-0(Hazardous Substances Data)

Upstream product

• 201856-48-6 (3R,4S)-3-<((R^*)-1'-ethoxyethyl)oxy>-4-phenyl-2-azetidinone 
• 132127-34-5 (3R,4S)-3-hydroxy-4-phenylazetidin-2-one 
• 100-52-7 benzaldehyde 
• 17599-61-0 N-benzylidene-1,1,1-trimethylsilanamine 
• 201856-53-3 (3R,4S)-3-(1-ethoxyethoxy)-4-(phenyl)-N-benzoyl-2-azetidinone 
• 95603-44-4 7,10-di(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III 

Downstream Products

• 114915-18-3 10-Deacetyl-7,10-bis(trichloroethoxycarbonyl)-taxol 

Relevant articles and documents

New and efficient approaches to the semisynthesis of taxol and its C-13 side chain analogs by means of β-lactam synthon method

Highly efficient chiral ester enolate-imine condensation giving 3-hydroxy-4-aryl-β-lactams with excellent enantiomeric purity is successfully applied to the asymmetric synthesis of the enantiomerically pure taxol C-13 side chain, N-benzoyl-(2R,3S)-3-phenyl-isoserine and its analogs. (3R,4S)-N-benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone readily derived from the 3-hydroxy-4-phenyl-β-lactam is coupled with protected baccatin IIIs, followed by deprotection to give optically pure taxol and 10-deacetyl-7,10-bis(Troc)-taxol in good yields. Fully assigned 1H, 13C, and 2D (COSY and HETCOR) NMR spectra of taxol thus synthesized are shown and discussed.