1446428-09-6

Basic information

• Product Name: 1-tosyl-4-(trifluoromethyl)-1H-indole
• Synonyms: 1-tosyl-4-(trifluoromethyl)-1H-indole
• CAS NO: 1446428-09-6
• Molecular Weight: 339.338
• Mol File: 1446428-09-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-tosyl-4-(trifluoromethyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tosyl-4-(trifluoromethyl)-1H-indole(1446428-09-6)
• EPA Substance Registry System: 1-tosyl-4-(trifluoromethyl)-1H-indole(1446428-09-6)

Safety Data

• Hazardous Substances Data: 1446428-09-6(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 81038-28-0 4-nitro-1-tosyl-1H-indole 
• 4769-97-5 4-nitro-1H-indoIe 
• 81038-31-5 1-tosyl-1H-indol-4-amine 

Relevant articles and documents

Conversion of aromatic amino into trifluoromethyl groups through a Sandmeyer-type transformation

A novel strategy for aromatic trifluoromethylation by converting amino into trifluoromethyl groups via a Sandmeyer-type reaction is reported. The transformation involves diazotization of the aromatic amines with tert-butyl nitrite and hydrochloric acid to form aryldiazonium chlorides, followed by trifluoromethylation with trifluoromethylsilver at low temperature. Various readily available aromatic amines are smoothly converted under mild conditions. Georg Thieme Verlag Stuttgart. New York.