81038-31-5

Usage

Derivative of indole

Indole is the parent compound from which 1-tosyl-1H-indol-4-amine is derived.

Physical appearance

Pale yellow solid This describes the color and form of 1-tosyl-1H-indol-4-amine.

Molecular weight

290.34 g/mol The mass of one mole of 1-tosyl-1H-indol-4-amine.

Use in organic synthesis

Versatile building block 1-tosyl-1H-indol-4-amine is a valuable intermediate compound used in the synthesis of various indole-containing compounds.

Applications

Pharmaceutical, dyes, and agrochemicals The compound is used in the preparation of different products, including medicines, dyes, and chemicals for agricultural use.

Intermediate in synthesis

Indole derivatives and biologically active compounds 1-tosyl-1H-indol-4-amine serves as an intermediate in the production of other indole-based compounds and those with biological activity.

Chemical structure and properties

Valuable and versatile in organic chemistry The unique structure and properties of 1-tosyl-1H-indol-4-amine make it an important and useful compound in the field of organic chemistry.

Upstream product

• 81038-27-9 methyl 2-hydroxy-2-(4-nitroindol-1-yl)-acetate 
• 52488-36-5 4-bromo-1H-indole 
• 98-59-9 p-toluenesulfonyl chloride 
• 72-18-4 L-valine 
• 90481-72-4 4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indole 
• 95969-07-6 5-chloro-4-oxo-N-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole 
• 81038-28-0 4-nitro-1-tosyl-1H-indole 
• 4769-97-5 4-nitro-1H-indoIe 
• 81038-26-8 methyl 2-(4-nitroindole-1-yl)oxyacetate 
• 78283-23-5 4-nitro-1-hydroxyindole 

Downstream Products

• 2380-94-1 1H-indol-4-ol 
• 1446428-09-6 1-tosyl-4-(trifluoromethyl)-1H-indole 
• 90481-72-4 4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indole 
• 211295-21-5 1-methoxy-2-(1-tosyl-1H-indol-4-yl)-1H-indole 
• 81038-38-2 4-iodo-1H-indole 
• 81038-34-8 1-(p-toluenesulphonyl)-4-hydroxyindole 

Relevant academic research and scientific papers

Modular Total Synthesis of Protein Kinase C Activator (-)-Indolactam v

A concise, eight-step total synthesis of (-)-indolactam V, a nanomolar agonist of protein kinase C, is reported. The synthesis relies upon an efficient copper-catalyzed amino acid arylation to establish the indole C4-nitrogen bond. This cross-coupling met

Amination-Oxidation Strategy for the Copper-Catalyzed Synthesis of Monoarylamines

A novel approach for the synthesis of monoarylamines from aryl halides is presented. This method employs an inexpensive, nontoxic metal source (copper) and incorporates a stable ammonia surrogate (α-amino acids), obviating the need for special experimental setup or handling of ammonia reagents. This process, which is proposed to proceed via an amination-oxidation sequence, selectively promotes the transformation of a range of aryl and heteroaryl iodides as well as bromides to the corresponding monoarylamines.

Silver-mediated trifluoromethylation of aryldiazonium salts: Conversion of amino group into trifluoromethyl group

A novel strategy for aromatic trifluoromethylation by converting aromatic amino group into CF3 group is reported herein. This method, which can be considered as trifluoromethylation variation of the classic Sandmeyer reaction, uses readily available aromatic amines as starting materials and is performed under mild conditions.

A FACILE ONE STEP SYNTHESIS OF 4-AMINOINDOLES FROM 5-HALO-4-OXO-4,5,6,7-TETRAHYDROINDOLES

Reaction of 5-halo-4-oxo-4,5,6,7-tetrahydroindoles with amines initiates the amination of the carbonyl function and ensuing dehydrohalogenation leads to a successful formation of 4-aminoindoles.