1446434-04-3Relevant articles and documents
Asymmetric Synthesis of Monofluorinated 1-Amino-1,2-dihydronaphthalene and 1,3-Amino Alcohol Derivatives
Lázaro, Rubén,Román, Raquel,Sedgwick, Daniel M.,Haufe, Günter,Barrio, Pablo,Fustero, Santos
, p. 948 - 951 (2016/03/15)
Enantioenriched 1-amino-4-fluoro-1,2-dihydronaphthalene derivatives are accessed via two complementary synthetic strategies. The careful optimization of the reaction conditions required for the elimination step in one route has allowed both the identification of an anchimerically assisted reaction pathway and, more importantly, access to a divergent reaction pathway toward fluorinated 1,3-amino alcohols from a common intermediate just by adjusting the number of equivalents of base used.
Asymmetric allylation/ring closing metathesis: One-pot synthesis of benzo-fused cyclic homoallylic amines. Application to the formal synthesis of Sertraline derivatives
Fustero, Santos,Lazaro, Ruben,Herrera, Lidia,Rodriguez, Elsa,Mateu, Natalia,Barrio, Pablo
, p. 3770 - 3773 (2013/08/23)
A one-pot asymmetric allylation/ring closing metathesis (RCM) sequence for the synthesis of cyclic homoallylic amines has been developed. A library of six- and seven-membered benzo-fused products has been synthesized in good yields and complete diastereoselectivity. The new methodology has been applied to the formal syntheses of the antidepressant Sertraline and the epimeric Norsertraline. The methodology is amenable for the synthesis of analogs.
