1446450-13-0

Basic information

• Product Name: 2,3-dichlorophenylhydroxymethylenebisphosphonic acid
• CAS NO: 1446450-13-0
• Molecular Weight: 336.99
• Mol File: 1446450-13-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,3-dichlorophenylhydroxymethylenebisphosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dichlorophenylhydroxymethylenebisphosphonic acid(1446450-13-0)
• EPA Substance Registry System: 2,3-dichlorophenylhydroxymethylenebisphosphonic acid(1446450-13-0)

Safety Data

• Hazardous Substances Data: 1446450-13-0(Hazardous Substances Data)

Upstream product

• 50-45-3 2,3-dichlorbenzoic acid 
• 2905-60-4 2,3-dichlorobenzoyl chloride 

Relevant articles and documents

Synthesis and evaluation of effective inhibitors of plant δ1-pyrroline-5-carboxylate reductase

Analogues of previously studied phenyl-substituted aminomethylene- bisphosphonic acids were synthesized and evaluated as inhibitors of Arabidopsis thaliana δ1-pyrroline-5-carboxylate reductase. With the aim of improving their effectiveness, two main modifications were introduced into the inhibitory scaffold: the aminomethylenebisphosphonic moiety was replaced with a hydroxymethylenebisphosphonic group, and the length of the molecule was increased by replacing the methylene linker with an ethylidene chain. In addition, chlorine atoms in the phenyl ring were replaced with various other substituents. Most of the studied derivatives showed activity in the micromolar to millimolar range, with two of them being more effective than the lead compound, with concentrations inhibiting 50% of enzyme activity as low as 50 μM. Experimental evidence supporting the ability of these inhibitors to interfere with proline synthesis in vivo is also shown.