144754-28-9Relevant academic research and scientific papers
Enantiospecific and Diastereoselective Synthesis of cis Monobactams through Electrophilic Amination of Chiral 3-Hydroxyesters
Banfi, Luca,Cascio, Giuseppe,Guanti, Giuseppe,Manghisi, Elso,Narisano, Enrica,Riva, Renata
, p. 11967 - 11982 (2007/10/02)
A new efficient entry into cis monobactams starting from β-hydroxyesters is reported.This preparation is based on the stereoselective "electrophilic amination" of β-hydroxyester dianions and on Miller's biomimetic synthesis of the β-lactam nucleus.By this route, key intermediates for the preparation of pharmacologically important cis aztreonam 2 and carumonam 3 were prepared.
Microbiological enantioselective synthesis of (S) and (R) 4-(p-anisyloxy)-3-hydroxybutyrates as new chiral building blocks for the synthesis of β-lactam antibiotics
Banfi, Luca,Cascio, Giuseppe,Ghiron, Chiara,Guanti, Giuseppe,Manghisi, Elso,Narisano, Enrica,Riva, Renata
, p. 11983 - 11994 (2007/10/02)
Both enantiomers of 4-p-anisyloxy-3-hydroxybutanoates 4 have been prepared in high e.e. by reduction of the corresponding β-ketoesters or β-ketocarboxylates with immobilized fermenting baker's yeast. The utility of these new chiral building blocks in the
