1447605-64-2

Upstream product

• 480-66-0 2,4,6-trihydroxyacetophenone 
• 115623-29-5 2-benzyloxy-4,6-bis(methoxymethyloxy)acetophenone 
• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 
• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 1365536-83-9 1-(2-(benzyloxy)-6-hydroxy-4-(methoxymethoxy)phenyl)ethan-1-one 

Downstream Products

• 1365537-65-0 C₃₈H₃₄O₇ 
• 1365537-61-6 C₄₁H₄₀O₈ 
• 1365537-55-8 C₄₄H₅₂O₈Si 

Relevant academic research and scientific papers

Enantioselective synthesis of orthogonally protected (2R,3R)-(-)- epicatechin derivatives, key intermediates in the de novo chemical synthesis of (-)-epicatechin glucuronides and sulfates

Ten orthogonally protected (-)-epicatechin and 3′- or 4′-O-methyl-(-)-epicatechin derivatives were prepared in a regiospecific and enantioselective manner. For each orthogonally protected (-)-epicatechin derivative, one specific phenolic hydroxyl was protected with a methoxymethyl (MOM) or p-methoxybenyzl (PMB) group and the remainder were protected as benzyl ethers. These uniquely protected (-)-epicatechin derivatives were designed to facilitate the regiospecific installation of a glucuronic acid or sulfate unit onto (-)-epicatechin after selective removal of the MOM or PMB protecting group to provide authentic standards of (-)-epicatechin glucuronides and sulfates.