1365536-83-9

Upstream product

• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 
• 115623-29-5 2-benzyloxy-4,6-bis(methoxymethyloxy)acetophenone 
• 100-39-0 benzyl bromide 
• 13057-17-5 bromethyl methyl ether 
• 39548-86-2 1‐(2‐(benzyloxy)‐4,6‐dihydroxyphenyl)ethan‐1‐one 
• 480-66-0 2,4,6-trihydroxyacetophenone 

Downstream Products

• 1429227-33-7 (E)-1-(2-benzyloxy-6-hydroxy-4-methoxymethoxyphenyl)-3-(4-benzyloxy-3-methoxyphenyl)propenone 
• 32769-01-0 tricin-7-β-D-glucopyranoside 
• 1365536-86-2 C₃₂H₃₀O₇ 

Relevant academic research and scientific papers

Total synthesis of Daphnodorin A

A total synthesis of Daphnodorin A, a member of the Daphnodorins, was accomplished. Key features of the synthetic strategy include construction of 2-substituted-3-functionalized benzofuran via intramolecular Heck reaction and a mild Barton-McCombie deoxyg

Enantioselective synthesis of orthogonally protected (2R,3R)-(-)- epicatechin derivatives, key intermediates in the de novo chemical synthesis of (-)-epicatechin glucuronides and sulfates

Ten orthogonally protected (-)-epicatechin and 3′- or 4′-O-methyl-(-)-epicatechin derivatives were prepared in a regiospecific and enantioselective manner. For each orthogonally protected (-)-epicatechin derivative, one specific phenolic hydroxyl was protected with a methoxymethyl (MOM) or p-methoxybenyzl (PMB) group and the remainder were protected as benzyl ethers. These uniquely protected (-)-epicatechin derivatives were designed to facilitate the regiospecific installation of a glucuronic acid or sulfate unit onto (-)-epicatechin after selective removal of the MOM or PMB protecting group to provide authentic standards of (-)-epicatechin glucuronides and sulfates.

A versatile approach to the regioselective synthesis of diverse (-)-epicatechin-β-d-glucuronides

A versatile new approach is reported for the total synthesis of five glucuronide metabolites of epicatechin, using selective protection/deprotection techniques.