144765-19-5Relevant academic research and scientific papers
Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates
Yang, Ming-Hsiu,Hunt, Jordan R.,Sharifi, Niusha,Altman, Ryan A.
, p. 9080 - 9083 (2016)
A palladium-catalyzed decarboxylative benzylation reaction of α,α-difluoroketone enolates is reported, in which the key C(α)?C(sp3) bond is generated by reductive elimination from a palladium intermediate. The transformation provides convergent access to α-benzyl-α,α-difluoroketone-based products, and should be useful for accessing biological probes.
Mechanochemical electrophilic fluorination of liquid beta-ketoesters
Howard, Joseph L.,Sagatov, Yerbol,Browne, Duncan L.
, p. 3118 - 3123 (2017/12/26)
An improved substrate scope for the mechanochemical electrophilic fluorination of dicarbonyls is reported. The applicable substrates have now been broadened to include liquid β-ketoesters. Key to this capability is the inclusion of a grinding auxiliary (NaCl) to improve mass transfer and prevent pasting or gumming of the reaction mixture. Notably, the use of a small amount of acetonitrile is critical to increasing the rate of reaction, ensuring complete consumption of starting materials during the short reaction times as well as improving the selectivity for the monofluorinated product in the mill.
Synthesis of 5-fluoro-1,3-dioxin-4-ones: Novel alternatives to α-fluorinated acyl ketenes
Iwaoka,Murohashi,Sato,Kaneko
, p. 977 - 981 (2007/10/02)
Fluorination of 5,6-unsubstituted 1,3-dioxin-4-ones and their 6-substituted derivatives by molecular fluorine followed by treatment with an appropriate organic base affords the title compounds, which can be converted either into heterocyclic compounds or into acylacetic acid derivatives having a fluorine atom.
