1447720-84-4

Upstream product

• 1447721-11-0 (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-ol 
• 133485-25-3 bis(diisopropylamino)(2-cyanoethoxy)phosphane 
• 204-02-4 1-H-perimidine 
• 479-27-6 naphthalene-1,8-diamine 
• 1447720-48-0 ((2R,3S,5R)-3-((4-methylbenzoyl)oxy)-5-(1H-perimidin-1-yl)tetrahydrofuran-2-yl)methyl 4-methylbenzoate 
• 3056-12-0 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythropentofuranosyl chloride 
• 1430339-86-8 (2R,3S,5R)-2-(hydroxymethyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-ol 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 

Relevant academic research and scientific papers

Hydrogen bonding or stacking interactions in differentiating duplex stability in oligonucleotides containing synthetic nucleoside probes for alkylated DNA

Oligonucleotides that hybridize to modified DNA are useful chemical tools to probe the noncovalent interactions that stabilize DNA duplexes. In an effort to better understand the interactions that influence the specificity of hybridization probes for Osu

Tolerance of base pair size and shape in postlesion DNA synthesis

The influence of base pair size and shape on the fidelity of DNA polymerase-mediated extension past lesion-containing mispairs was examined. Primer extension analysis was performed with synthetic nucleosides paired opposite the pro-mutagenic DNA lesion O6-benzylguanine (O 6-BnG). These data indicate that the error-prone DNA polymerase IV (Dpo4) inefficiently extended past the larger Peri:O6-BnG base pair, and in contrast, error-free extension was observed for the smaller BIM:O 6-BnG base pair. Steady-state kinetic analysis revealed that Dpo4 catalytic efficiency was strongly influenced by the primer:template base pair. Compared to the C:G pair, a 1.9- and 79 000-fold reduction in Dpo4 efficiency was observed for terminal C:O6-BnG and BIM:G base pairs respectively. These results demonstrate the impact of geometrical size and shape on polymerase-mediated mispair extension.