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Usage

Uses

Used in Neurogenesis Applications:
Neurodazine is used as a neurogenesis inducer for non-pluripotent C2C12 myoblasts and cells derived from mature human skeletal muscle. It promotes the upregulation of genes involved in neurogenesis, particularly the B-cell translocation gene 2, without affecting genes related to myogenesis.
Used in Pharmaceutical Industry:
Neurodazine is used as a pharmaceutical compound for the development of treatments targeting neurodegenerative diseases and promoting neural regeneration. Its ability to induce neurogenesis in mature skeletal muscle cells makes it a promising candidate for therapeutic applications in regenerative medicine and neuroprotection.

Biochem/physiol Actions

Neurodazine is a promoter of neurogenesis. It induces a generation of new nerve cells from skeletal muscle fibers both immature, differentiated myotubes and mature skeletal muscle. Neurodazine promotes the expression of neuron-specific markers in treated C2C12 cells (neurogenesis). In addition, in conjunction with a microtubule-destabilizing agent, Neurodazine allows neurogenic conversion of both differentiated immature myotubes and mature skeletal muscle. Neurodazine is a potential alternative approach to using stem cells.

References

1) Williams?et al. (2007),?Synthetic small molecules that induce neurogenesis in skeletal muscle; J. Am. Chem. Soc.,?129?9258

Upstream product

• 22078-59-7 5-(3-chlorophenyl)-2-furancarboxaldehyde 
• 1226-42-2 1,2-bis(4-methoxyphenyl)-1,2-ethanedione 
• 1448032-43-6 1-benzyl-4,5-dibromo-2-(2-furyl)-1H-imidazole 
• 1448032-47-0 4,5-dibromo-2-(2-furyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole 
• 1448032-60-7 1-benzyl-2-(furan-2-yl)-4,5-(4-methoxyphenyl)-1H-imidazole 
• 1448032-67-4 2-(2-furyl)-4,5-di(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole 
• 1448032-71-0 1-benzyl-2-(5-bromofuran-2-yl)-4,5-di(4-methoxyphenyl)-1H-imidazole 
• 1448032-72-1 2-(5-bromofuran-2-yl)-4,5-di(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole 
• 1448032-73-2 1-benzyl-2-(5-(3-chlorophenyl)furan-2-yl)-4,5-bis(4-methoxyphenyl)-1H-imidazole 
• 1448032-74-3 2-[5-(3-chlorophenyl)furan-2-yl]-4,5-di(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole 

Relevant academic research and scientific papers

Synthetic small molecules that induce neurogenesis in skeletal muscle

Neurons are not regenerated effectively, and their injury causes neurodegenerative diseases. These diseases may be treated by the transplantation of neural stem cells. However, ethical and technical issues restrict cell therapies using neural stem cells.

Triorganoindium reagents in selective palladium-catalyzed cross-coupling with iodoimidazoles: Synthesis of neurodazine

Triorganoindium reagents (R3In, R = aryl, heteroaryl, alkynyl) react selectively under palladium catalysis with N-benzyl-2,4,5-triiodoimidazole to afford the C-2 monocoupling products. The reaction proceeds efficiently for a variety of aryl- and heteroarylindium reagents with the transfer of all three organic groups attached to the metal. The coupling products can be used in a subsequent two-fold cross-coupling to give trisubstituted imidazoles in good yields. This approach was employed to synthesize neurodazine and analogues in good yields. (Chemical Equation Presented).

Selective sequential cross-coupling reactions on imidazole towards neurodazine and analogues

Polysubstituted imidazoles represent a common structural motif in bioactive molecules. A modular and flexible strategy towards 2,4,5-triarylated imidazoles is reported applying a Suzuki-Miyaura cross-coupling protocol. Employing 1-protected 2,4,5-tribromoimidazole as starting material, both stepwise and one-pot protocols towards the title compounds are disclosed. The utility of the approach was demonstrated by synthesizing neurodazine, a biologically active molecule affecting neuronal cell differentiation.

Compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for in

The present invention relates to compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying a

COMPOUNDS INDUCING DIFFERENTIATION OF MYOBLASTS OR MUSCLE FIBERS INTO NEURON CELLS, PHARMACEUTICAL COMPOSITION INCLUDING SAID COMPOUNDS, A METHOD FOR INDUCING NEURON DIFFERENTIATION AND A SCREENING METHOD FOR IDENTIFYING ADDITIONAL COMPOUNDS USEFUL FOR IN

The present invention relates to compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying a