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Deflazacort CAS 14484-47-0
Cas No: 14484-47-0
USD $ 8.5-10.5 / Kilogram 10 Kilogram 100 Kilogram/Month Antimex Chemical Limied Contact Supplier
Cas No: 14484-47-0
No Data 1 Gram 10000 Kilogram/Day Ningbo Kichem Co.,Ltd. Contact Supplier
Deflazacort Powder API CAS Rn14484-47-0
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USD $ 1900.0-2000.0 / Kilogram 1 Kilogram 200 Kilogram/Month Wuhan Jing Chu Chen Pharmaceutical Chemical Co., Ltd. Contact Supplier
Deflazacort Manufacturer/High quality/Best price/In stock
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USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Deflazacort CAS 14484-47-0
Cas No: 14484-47-0
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
High purity Various Specifications Deflazacort CAS:14484-47-0
Cas No: 14484-47-0
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
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USD $ 50.0-50.0 / Metric Ton 10 Metric Ton 10 Kilogram/Day Henan DaKen Chemical CO.,LTD. Contact Supplier
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No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
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No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Cas No: 14484-47-0
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier

14484-47-0 Usage




Compound 10g (1) was dissolved in 350ml methanol, and then added 8.3g of semicarbazide hydrochloride and 5.75ml of pyridine in 50ml of water, after the reaction. We can obtain compound 11g (Ⅱ). Compound 9g (Ⅱ) was dissolved 230ml 95% ethanol, the solution was added 3.6g of potassium carbonate and 2.34g of sodium borohydride in 36ml of water, which was refluxed for 30min and then added 2.34g of sodium borohydride. After the reaction, we can obtain compound 8.5g (Ⅲ). Compound 7.7g (Ⅲ) was dissolved in 154ml 10% hydrochloric acid in methanol, refluxed for 1h, to give Compound 6g (Ⅳ). Compound 12.5g (Ⅳ) was dissolved in 500ml of anhydrous toluene and 90ml of cyclohexanone. It was added 6.24g triisopropyl aluminum, 9g obtained by reacting the compound (V). 6.5g compound (V) was dissolved in 123ml dry dioxane, and 25% hydrogen bromide in acetic acid solution is heated, and then added 5.5g of bromine in dioxane; the reaction solution was poured into the water, collected by filtration after the crystals were carefully dried, redissolved in dimethylformamide. It  was added 7.5g of lithium bromide and lithium carbonate (1: 2) mixture. After heating the reaction, we can obtain the compound 5.1g (ⅵ). 2g compound (Ⅵ) was dissolved in tetrahydrofuran-methanol (1: 1), added to 3.9g calcium oxide and 0.1g of azobisisobutyronitrile. It was added 2g of iodine in tetrahydrofuran-methanol mixture; After the reaction was filtered off precipitate , which was dissolved in acetone,  it was then added triethylamine 20ml, 20ml and 12ml acetone, acetic acid, atter the reaction, we can obtain 1.6g deflazacort.

Drug interactions

  • Cardiff may have unique row potassium, and it should pay more attention when combined with diuretics.
  • When combined with the drug having enzymatic action (rifampicin, phenobarbital, etc.), the corticosteroids should be properly increment.
  • Erythromycin, estrogen can inhibit the activity of this product and the metabolism, when combined with appropriate reductions.


  • Like other glucocorticoids, it is general contraindicated in systemic infections.
  • Used with caution in diverticulitis, recent gastrointestinal surgery, renal failure, hypertension, diabetes, osteoporosis, myasthenia gravis embolism. Pregnancy and lactation women should used with caution.


 The third generation of corticosteroids, anti-inflammatory, anti-allergy, increased gluconeogenesis and so on. For the use of the primary and secondary adrenocortical insufficiency, rheumatism, collagen diseases, skin diseases, allergic diseases, eye diseases, and fulminant disseminated tuberculosis, hematopoietic system disorders, ulcerative colitis, idiopathic nephrotic syndrome, and other hematopoietic malignancies.

Chemical Properties

Off-White to Pale Yellow Solid

Adverse effects

Deflazacort carries the risks common to all corticosteroids, including immune suppression, decreased bone density, and endocrine insufficiency. In clinical trials, the most common side effects (>10% above placebo) were Cushing's-like appearance, weight gain, and
increased appetite.
Long-term medication can affect the normal growth of children, induced peptic ulcer perforation, which can cause euphoria, depression, insomnia and other psychiatric symptoms. Sudden withdrawal after long-term use can cause secondary adrenal insufficiency withdrawal reactions, which should gradually decrease until disabled.


A systemic corticosteroid. A derivative of prednisolone. Used for rheumatoid arthritis and lupus




Deflazacort (trade name Emflaza among others) is a glucocorticoid used as an anti-inflammatory and immunosuppressant. It belongs to a group of medicines called corticosteroids. It is sometimes referred to simply as an oral steroid.
Deflazacort is an inactive prodrug which is metabolized rapidly to the active drug 21-desacetyldeflazacort.It is used to treat a wide variety of conditions. Some examples include autoimmune diseases (for example, systemic lupus erythematosus (SLE), autoimmune hepatitis, sarcoidosis), joint and muscle diseases (for example, rheumatoid arthritis), and allergies and asthma.
Cardiff can be specially designed for the third generation of corticosteroids, anti-inflammatory, anti-allergy, and it increased gluconeogenesis and so on. It acts as prednisolone 10~20 times of the dragon, 40 times as hydrocortisone. This product has no mutagenic effect. This product, labeled with C14 study, shows that the product of the gastrointestinal tract rapidly absorbed, reaching the peak blood concentration after 1~2h, forming the active substance by hydrolysis, and the latter further metabolic processes is similar with other corticosteroids, as well as the active metabolite T1/2 is 2 h and the rats are mainly distributed in the kidney and hematopoietic system and other organizations.
deflazacort formula
Figure 1 is a deflazacort formula.

Chemical Properties

Acetone-hexane, m.p. 255-256.5 ℃. [Α] D + 62.3 ° (C = 0.5, chloroform). UV absorption maximum (methanol): 241~242nm (E1cm1% 352.5). Acute toxicity LD50 in mice (mg/kg): 5200 oral; 1610 subcutaneous injection. Rats Acute toxicity LD50 (mg/kg): 109 subcutaneously. Dog Acute toxicity LD50 (mg/kg):> 4000 Oral; 50 subcutaneous injection.

14484-47-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (SML0123)  Deflazacort  ≥98% (HPLC) 14484-47-0 SML0123-50MG 4,559.49CNY Detail
Sigma (SML0123)  Deflazacort  ≥98% (HPLC) 14484-47-0 SML0123-10MG 1,130.22CNY Detail
USP (1166116)  Deflazacort  United States Pharmacopeia (USP) Reference Standard 14484-47-0 1166116-100MG 4,326.66CNY Detail
TCI America (D4523)  Deflazacort  >98.0%(HPLC)(N) 14484-47-0 5g 2,790.00CNY Detail
TCI America (D4523)  Deflazacort  >98.0%(HPLC)(N) 14484-47-0 1g 850.00CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name Deflazacort

1.2 Other means of identification

Product number -
Other names 11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14484-47-0 SDS

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