1448419-13-3

Usage

Classification

Naphthyridine derivative with carbonitrile functional group

Functional Groups

Acetyl substituent at position 2
Chloro group attached to the benzylamine moiety
Methoxy group attached to the benzylamine moiety
Carbonitrile group at position 8

Potential Pharmaceutical Applications

Structural features and functional groups suggest potential for drug development or medicinal research

Synthetic Complexity

Challenging molecule to synthesize and study in laboratory settings due to its chemical complexity

Upstream product

• 52727-57-8 5-bromo-2-aminobenzoic acid methyl ester 
• 1448419-29-1 2-acetyl-10-chloro-1,2,3,4-tetrahydrobenzo[b][1,6]-naphthyridine-8-carbonitrile 
• 41965-95-1 (3-chloro-4-methoxyphenyl)methylamine hydrogen chloride 
• 1448419-26-8 10-chloro-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile 
• 1448419-25-7 2-benzyl-10-chloro-1,2,3,4-tetrahydrobenzo[b][1,6]-naphthyridine-8-carbonitrile 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 99767-45-0 2-amino-5-cyanobenzoic acid 

Relevant academic research and scientific papers

Phosphodiesterase inhibitors and uses thereof

The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibitio

Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease

Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) leading to increased levels of the cAMP response element binding protein (CREB), a transcriptional factor involved with learning and memory processes. We previously reported poten

NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF

The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibitio

NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF

The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibitio