1448514-05-3

Basic information

• Product Name: 1-(4-(2,4-dichlorophenyl)thiazol-2-yl)-2-(pentan-2-ylidene)hydrazine
• Synonyms: 1-(4-(2,4-dichlorophenyl)thiazol-2-yl)-2-(pentan-2-ylidene)hydrazine
• CAS NO: 1448514-05-3
• Molecular Weight: 328.265
• Mol File: 1448514-05-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-(2,4-dichlorophenyl)thiazol-2-yl)-2-(pentan-2-ylidene)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(2,4-dichlorophenyl)thiazol-2-yl)-2-(pentan-2-ylidene)hydrazine(1448514-05-3)
• EPA Substance Registry System: 1-(4-(2,4-dichlorophenyl)thiazol-2-yl)-2-(pentan-2-ylidene)hydrazine(1448514-05-3)

Safety Data

• Hazardous Substances Data: 1448514-05-3(Hazardous Substances Data)

Upstream product

• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 107-87-9 2-Pentanone 
• 1752-39-2 propylmethyl ketone thiosemicarbazone 
• 2631-72-3 2,4-dichlorophenacyl bromide 

Relevant articles and documents

Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents

Thirty-eight new (4-(4-substituted-phenyl/2,4-disubstituted-phenyl)- thiazol-2-yl)hydrazine derivatives were synthesized in good yield and assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-two clinical isolates of Candida spp. The concurrent presence of aliphatic chains or cycloaliphatic rings at N1-hydrazine and a 4-methyl/4-methoxyphenyl at C4 position of the thiazole nucleus exhibited an interesting anti-Candida inhibitory activity. Moreover, some of the most active compounds showed synergistic antifungal effects and lower cell toxicity when combined with clotrimazole.