144852-07-3

Upstream product

• 96994-77-3 3-iodopropionaldehyde dimethylacetal 
• 3769-41-3 3-Benzyloxyphenol 
• 1700-37-4 3-Benzyloxybenzaldehyde 
• 108-46-3 recorcinol 
• 100-44-7 benzyl chloride 

Downstream Products

• 1983-72-8 medicagol 
• 58536-23-5 7,11,12-Tribenzyloxycoumestan 
• 19839-21-5 3-Benzyloxy-5,8,10,12-tetraoxa-benzo[a]cyclopenta[h]fluoren-6-one 
• 76240-26-1 (+/-)-3-benzyloxymaackiain 
• 336131-20-5 3,8-bis-benzyloxy-9-methoxy-6a,11a-dihydro-6H-benzo[4,5]furo[3,2-c]chromene 
• 336131-22-7 3,8,9-tris-benzyloxy-6a,11a-dihydro-6H-benzo[4,5]furo[3,2-c]chromene 
• 494205-19-5 4-benzenesulfonyl-7-benzyloxy-2H-chromene 
• 494205-23-1 1-(4-benzyloxy-2-hydroxy-phenyl)-2-phenyl-propenone 
• 26200-05-5 7-benzyloxy-isoflavanone 
• 13360-66-2 3'-methoxycoumestrol 
• 916754-96-6 3,9-bis-benzyloxy-8-methoxy-benzo[4,5]furo[3,2-c]chromen-6-one 
• 76240-25-0 7-benzyloxy-2H-1-benzopyran 

Relevant academic research and scientific papers

Structure-activity relationship of wedelolactone analogues: Structural requirements for inhibition of Na+,K+-ATPase and binding to the central benzodiazepine receptor

Coumestans 2a-i, bearing different patterns of substitution in A- and D-rings, were synthesized and evaluated as inhibitors of kidney Na+,K+-ATPase and ligands for the central benzodiazepine (BZP) receptor. The presence of a hydroxyl group in position 2 favours the effect on Na+,K+-ATPase but decreases the affinity for the BZP receptor, allowing the design of more selective molecules than the natural wedelolactone. On the other hand, the presence of a catechol in ring D is important for the effect on both molecular targets.

4-Chromenesulphones: Synthesis and transformation to isoflavonoid models

Novel sulphones derived from chromenes through substitution at C-4 were prepared. It has been shown that, after conjugate addition of phenyl lithium and sulphone function manipulation on the adducts, these molecules lead to isoflavan, isoflavene and isoflavanone models.

Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation

Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound (2b, IC50 = 1 μM) was selected for study of

A convenient synthesis of (±)-4-prenylpterocarpin

Coupling of 7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran (4a) with 2-chloromercurio-4,5-methylenedioxyphenol (5) yields (±)-6a,12a-cis-dihydro-3-methoxy-4-(3-methyl-2-butenyl)-6H-[1,3]diox olo[5,6]benzofuro[3,2-c][1]benzopyran (6; ±-4-prenylpterocarpi